myog myogenin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: myogprovided by ZNC
Official Full Name: myogeninprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-265
See related: Ensembl:ENSDARG00000009438 AllianceGenome:ZFIN:ZDB-GENE-980526-265
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb553; zgc:100763
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including positive regulation of myoblast fusion; response to activity; and skeletal muscle tissue regeneration. Predicted to be located in nucleus. Is expressed in several structures, including mesoderm; musculature system; myoblast; post-vent region; and trunk. Orthologous to human MYOG (myogenin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (22596581..22599615, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (22436013..22438999, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis.
Title: Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis.
The results show that myogenin gene expression is more sensitive to nutrient conditions of fish than traditional indicators such as the RNA/DNA ratio.
Title: Feeding restriction alters expression of some ATP related genes more sensitively than the RNA/DNA ratio in zebrafish, Danio rerio.
myog cannot rescue myogenesis in the myod/myf5 double morphant
Title: Induced early expression of mrf4 but not myog rescues myogenesis in the myod/myf5 double-morphant zebrafish embryo.
muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter
Title: Muscle-specific expression of myogenin in zebrafish embryos is controlled by multiple regulatory elements in the promoter.

Submit: New GeneRIF Correction

General gene information

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Markers

fb99g08.x1 (e-PCR)
- UniSTS:192018

fb99g08.x1 (e-PCR)
- UniSTS:192019

fb80e04.x1 (e-PCR)
- UniSTS:191557

fb80e04.x1 (e-PCR)
- UniSTS:191558

myog (e-PCR), detects polymorphism
- UniSTS:186996

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast differentiation involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast proliferation involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to activity	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle tissue development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myogenin

Names: Myf4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.