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    Efhb EF hand domain family, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301168, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Efhbprovided by RGD
    Official Full Name
    EF hand domain family, member Bprovided by RGD
    Primary source
    RGD:1566407
    See related
    Ensembl:ENSRNOG00000012618 AllianceGenome:RGD:1566407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566407
    Summary
    Predicted to enable calcium ion sensor activity. Predicted to be involved in negative regulation of protein binding activity; regulation of calcineurin-NFAT signaling cascade; and regulation of store-operated calcium entry. Orthologous to human EFHB (EF-hand domain family member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 50.6) and Lung (RPKM 15.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (6608791..6680104, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6372191..6441678, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (47988..120800)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene golgi SNAP receptor complex member 1, pseudogene 1 Neighboring gene RB binding protein 4, chromatin remodeling factor, pseudogene 1 Neighboring gene transmembrane protein 234-like Neighboring gene small nucleolar RNA SNORA70 Neighboring gene transfer RNA serine (anticodon AGA) 49 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction. Albarran L, et al. Cell Physiol Biochem, 2018. PMID 30481768
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing family member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106879.1 → NP_001100349.1  EF-hand domain-containing family member B

      See identical proteins and their annotated locations for NP_001100349.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474184
      UniProtKB/TrEMBL
      A6KUI0, A6KUI1
      Related
      ENSRNOP00000016911.6, ENSRNOT00000016911.7
      Conserved Domains (2) summary
      cd00051
      Location:585 → 646
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:585 → 645
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      6608791..6680104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266839.1 → XP_063122909.1  EF-hand domain-containing family member B isoform X3

    2. XM_039083162.1 → XP_038939090.1  EF-hand domain-containing family member B isoform X3

      Conserved Domains (1) summary
      pfam13499
      Location:278 → 342
      EF-hand_7; EF-hand domain pair

    3. XM_039083161.1 → XP_038939089.1  EF-hand domain-containing family member B isoform X2

      Conserved Domains (1) summary
      pfam13499
      Location:304 → 368
      EF-hand_7; EF-hand domain pair

    4. XM_063266838.1 → XP_063122908.1  EF-hand domain-containing family member B isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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