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    Pde1b phosphodiesterase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29691, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pde1bprovided by RGD
    Official Full Name
    phosphodiesterase 1Bprovided by RGD
    Primary source
    RGD:3278
    See related
    Ensembl:ENSRNOG00000036828 AllianceGenome:RGD:3278
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aop2; Pde1b1
    Summary
    Enables cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in cellular response to cytokine stimulus; monocyte differentiation; and signal transduction. Predicted to act upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Located in neuronal cell body. Biomarker of Parkinsonism. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 178.6), Kidney (RPKM 27.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q36
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136505834..136533034)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134627378..134654581)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (145117951..145147711)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547836 Neighboring gene gametocyte specific factor 2 Neighboring gene NCK associated protein 1 like Neighboring gene uncharacterized LOC134479586 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1A Neighboring gene glycosylation dependent cell adhesion molecule 1 Neighboring gene uncharacterized LOC102547969

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia. Hayes J, et al. Neuropharmacology, 2021 Mar 15. PMID 33444639
    2. Down-regulation of nitrergic transmission in the rat striatum after chronic nigrostriatal deafferentation. Sancesario G, et al. Eur J Neurosci, 2004 Aug. PMID 15305867
    3. Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme. Siuciak JA, et al. Neuropharmacology, 2007 Jul. PMID 17559891
    4. Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. Reed TM, et al. J Neurosci, 2002 Jun 15. PMID 12077213, Free PMC Article
    5. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. Santone R, et al. J Neurosci Res, 2006 Oct. PMID 16881052

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
      Title: Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cyclic-nucleotide phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect dopamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within serotonin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    Names
    63 kDa Cam-PDE
    anti-oxidant protein 2
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    cam-PDE 1B
    cyclic nucleotide phosphodiesterase (CaM-PDE)
    phosphodiesterase 1B, Ca2+calmodulin dependent
    phosphodiesterase 1B, calmodulin-dependent
    phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa
    phosphodiesterase IB calmodulin-dependent
    NP_073201.1
    XP_006242448.1
    XP_063119199.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022710.1 → NP_073201.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

      See identical proteins and their annotated locations for NP_073201.1

      Status: PROVISIONAL

      Source sequence(s)
      M94537
      UniProtKB/Swiss-Prot
      Q01066, Q548L3
      UniProtKB/TrEMBL
      A6KD12
      Related
      ENSRNOP00000052147.1, ENSRNOT00000055272.4
      Conserved Domains (2) summary
      pfam00233
      Location:221 → 448
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:80 → 136
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136505834..136533034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263129.1 → XP_063119199.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2

      UniProtKB/TrEMBL
      A6KD13

    2. XM_006242386.5 → XP_006242448.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANV0
      Related
      ENSRNOP00000095772.1
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 429
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01066.1 GenPept UniProtKB/Swiss-Prot:Q01066

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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