U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TUFM Tu translation elongation factor, mitochondrial [ Bos taurus (cattle) ]

    Gene ID: 281556, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TUFMprovided by VGNC
    Official Full Name
    Tu translation elongation factor, mitochondrialprovided by VGNC
    Primary source
    VGNC:VGNC:36517
    See related
    BGD:BT16417; Ensembl:ENSBTAG00000019216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 25
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (25967782..25971737)

    Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene uncharacterized LOC101908406 Neighboring gene SH2B adaptor protein 1 Neighboring gene ataxin 2 like Neighboring gene eukaryotic translation initiation factor 3, subunit C-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Chaperone properties of mammalian mitochondrial translation elongation factor Tu. Suzuki H, et al. J Biol Chem, 2007 Feb 9. PMID 17130126
    2. High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP. Andersen GR, et al. J Mol Biol, 2000 Mar 24. PMID 10715211
    3. Analysis of the functional consequences of lethal mutations in mitochondrial translational elongation factors. Akama K, et al. Biochim Biophys Acta, 2010 Jul-Aug. PMID 20435138, Free PMC Article
    4. Mutagenesis of Arg335 in bovine mitochondrial elongation factor Tu and the corresponding residue in the Escherichia coli factor affects interactions with mitochondrial aminoacyl-tRNAs. Hunter SE, et al. RNA Biol, 2004 Jul. PMID 17179748
    5. Crystal structure of the bovine mitochondrial elongation factor Tu.Ts complex. Jeppesen MG, et al. J Biol Chem, 2005 Feb 11. PMID 15557323

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of activity is caused by a significant reduction in the ability of EF-Ts(mt) R325W to bind EF-Tu(mt), leading to a defect in nucleotide exchange.
      Title: Analysis of the functional consequences of lethal mutations in mitochondrial translational elongation factors.
    2. The arginine residue at position 335 of bovine mitochondrial elongation factor Tu (EF-Tu) plays an important role in the binding and EF-Tu-mediated delivery of mitochondrial aminoacyl-tRNAs to the A-site of the ribosome.
      Title: Mutagenesis of Arg335 in bovine mitochondrial elongation factor Tu and the corresponding residue in the Escherichia coli factor affects interactions with mitochondrial aminoacyl-tRNAs.
    3. X-ray crystallographic structure of the EF-Tumt.Tsmt complex
      Title: Crystal structure of the bovine mitochondrial elongation factor Tu.Ts complex.
    4. Isolation, crystallisation, and preliminary X-ray analysis
      Title: Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes.
    5. Recombinant mitochondrial EF-Tu prevents thermal aggregation of proteins and enhances protein refolding in vitro.
      Title: Chaperone properties of mammalian mitochondrial translation elongation factor Tu.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC140641

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    elongation factor Tu, mitochondrial
    Names
    EF-Tu

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174207.2 → NP_776632.1  elongation factor Tu, mitochondrial precursor

      See identical proteins and their annotated locations for NP_776632.1

      Status: PROVISIONAL

      Source sequence(s)
      L38996
      UniProtKB/Swiss-Prot
      P49410, Q0VCL4
      Related
      ENSBTAP00000025586.2, ENSBTAT00000025586.3
      Conserved Domains (1) summary
      cl27768
      Location:47 → 437
      SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      25967782..25971737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49410.1 GenPept UniProtKB/Swiss-Prot:P49410

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous