CYBB cytochrome b-245 beta chain [Bos taurus (cattle)] - Gene

Summary

Official Symbol: CYBBprovided by VGNC
Official Full Name: cytochrome b-245 beta chainprovided by VGNC
Primary source: VGNC:VGNC:50265
See related: BGD:BT21708; Ensembl:ENSBTAG00000019953
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: NOX2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: X

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	X	NC_037357.1 (105600080..105633007, complement)

Chromosome X - NC_037357.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the efficiency of NADPH oxidase enzymatic activity is higher at endoplasmic reticulum (ER).
Title: Contribution of lipid environment to NADPH oxidase activity: influence of sterol.
A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C
Title: Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables superoxide-generating NAD(P)H oxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytochrome b-245 heavy chain

Names: CGD91-phox; NADPH oxidase 2; cytochrome b(558) subunit beta; cytochrome b-245, beta polypeptide; cytochrome b558 subunit beta; gp91-1; gp91-phox; heme-binding membrane glycoprotein gp91phox; neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174035.4 → NP_776460.1 cytochrome b-245 heavy chain

See identical proteins and their annotated locations for NP_776460.1

Status: PROVISIONAL

Source sequence(s)

BC134469

UniProtKB/Swiss-Prot

A4IF96, O46522

UniProtKB/TrEMBL

A0A3Q1LFX6

Related

ENSBTAP00000026580.4, ENSBTAT00000026580.5

Conserved Domains (2) summary

cd06186
Location:297 → 570

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:65 → 219

Ferric_reduct; Ferric reductase like transmembrane component