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    Gpr156 G protein-coupled receptor 156 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 260430, updated on 11-Apr-2024

    Summary

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    Symbol
    Gpr156provided by RGD
    Full Name
    G protein-coupled receptor 156provided by RGD
    Primary source
    RGD:708438
    See related
    Ensembl:ENSRNOG00000002797 AllianceGenome:RGD:708438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gababl
    Summary
    Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Orthologous to human GPR156 (G protein-coupled receptor 156). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 1.3), Adrenal (RPKM 1.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (76228104..76320890, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62722632..62815402, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (65285468..65350442, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene glycogen synthase kinase 3 beta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene ubiquitin-conjugating enzyme E2D 2, pseudogene 1 Neighboring gene leucine rich repeat containing 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability. Fairfax BP, et al. J Biol Chem, 2004 Mar 26. PMID 14707142
    2. Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor. Calver AR, et al. Brain Res Mol Brain Res, 2003 Feb 20. PMID 12591167
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GABAB receptor cell surface stability is modulated by phosphorylation and chronic agonist treatment
      Title: Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 156
    Names
    GABAB-related G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153295.2 → NP_695207.2  probable G-protein coupled receptor 156

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q8K451
      UniProtKB/TrEMBL
      A6IR84, G3V6C5
      Related
      ENSRNOP00000003773.1, ENSRNOT00000003773.3
      Conserved Domains (1) summary
      cd15292
      Location:48 → 317
      7tmC_GPR156; orphan GPR156, member of the class C family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      76228104..76320890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088048.2 → XP_038943976.1  probable G-protein coupled receptor 156 isoform X1

      UniProtKB/Swiss-Prot
      Q8K451
      Conserved Domains (2) summary
      cd14964
      Location:60 → 81
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:50 → 292
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K451.1 GenPept UniProtKB/Swiss-Prot:Q8K451

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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