Kcnb1 potassium voltage-gated channel subfamily B member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnb1provided by RGD
Official Full Name: potassium voltage-gated channel subfamily B member 1provided by RGD
Primary source: RGD:2954
See related: Ensembl:ENSRNOG00000046949 AllianceGenome:RGD:2954
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Shab; Kv2.1; DRK1PC; Kcr1-1
Summary: Enables several functions, including protein heterodimerization activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in several processes, including positive regulation of transport; potassium ion export across plasma membrane; and regulation of motor neuron apoptotic process. Acts upstream of or within potassium ion transport. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 97.7), Heart (RPKM 71.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (176239285..176332408, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (155820255..155913383, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (163850785..163935610, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kv2.1 Channels Prevent Vasomotion and Safeguard Myogenic Reactivity in Rat Small Superior Cerebellar Arteries.
Title: Kv2.1 Channels Prevent Vasomotion and Safeguard Myogenic Reactivity in Rat Small Superior Cerebellar Arteries.
Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1.
Title: Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1.
Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia.
Title: Tyrosine Phosphorylation of the K(v)2.1 Channel Contributes to Injury in Brain Ischemia.
Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvbeta1 subunit.
Title: Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvβ1 subunit.
A molecular rheostat: Kv2.1 currents maintain or suppress repetitive firing in motoneurons.
Title: A molecular rheostat: Kv2.1 currents maintain or suppress repetitive firing in motoneurons.
Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.
Title: Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.
results suggest that Kv2.1 clusters exert a spatially discrete homeostatic braking mechanism on dopamine transporter by inducing a relative increase in inward-facing transporters
Title: Clustered Kv2.1 decreases dopamine transporter activity and internalization.
Enhanced Kv2.1 potassium whole-cell currents.
Title: Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C-Derived Protein NS5A Targeting Kv2.1 Potassium Channels.
Kv2.1 forms reservoir clusters on the beta-cell plasma membrane and binds Syn-3 via its C-terminal C1b domain, which recruits newcomer insulin secretory granules into this large reservoir.
Title: K(v)2.1 clusters on β-cell plasma membrane act as reservoirs that replenish pools of newcomer insulin granule through their interaction with syntaxin-3.
up-regulation of the KV2.1 channel in renal artery myocytes may be involved in the compensatory mechanisms against decreased renal blood flow in salt-sensitive hypertension
Title: Up-Regulation of the Voltage-Gated K(V)2.1 K(+) Channel in the Renal Arterial Myocytes of Dahl Salt-Sensitive Hypertensive Rats.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131835 (e-PCR)
- UniSTS:215118

RH94649 (e-PCR)
- UniSTS:119896

Kcnb1 (e-PCR), detects polymorphism
- UniSTS:463211

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables delayed rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables delayed rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in action potential	IEA Inferred from Electronic Annotation more info
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in clustering of voltage-gated potassium channels	IDA Inferred from Direct Assay more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion-dependent exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of catecholamine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-term synaptic depression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic depression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of norepinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of motor neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle docking involved in exocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily B member 1

Names: DRK1; delayed rectifier potassium channel 1; potassium channel Kv2.1; potassium channel, voltage gated Shab-related subfamily B, member 1; potassium voltage gated channel, Shab-related subfamily, member 1; voltage-gated potassium channel subunit Kv2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013186.3 → NP_037318.2 potassium voltage-gated channel subfamily B member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P15387

UniProtKB/TrEMBL

A0A0H2UI34, A6JXI9

Related

ENSRNOP00000065961.3, ENSRNOT00000074023.3

Conserved Domains (3) summary

cd18412
Location:15 → 141

BTB_POZ_KCNB2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2)

pfam00520
Location:188 → 424

Ion_trans; Ion transport protein

pfam03521
Location:467 → 678

Kv2channel; Kv2 voltage-gated K+ channel