U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    dot2 ESCRT II complex subunit Dot2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541147, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    dot2
    Gene description
    ESCRT II complex subunit Dot2
    Primary source
    PomBase:SPBC651.05c
    Locus tag
    SPBC651.05c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    vps22
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1245920..1247116, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene nitrilase superfamily protein Neighboring gene GTPase-activating protein Gyp10 Neighboring gene uncharacterized protein Neighboring gene protein mug166 Neighboring gene uncharacterized protein Neighboring gene putative DNA-directed RNA polymerase III complex large subunit Rpc1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification. Jin Y, et al. Dev Cell, 2005 Jul. PMID 15992541
    2. Fission yeast mutants affecting telomere clustering and meiosis-specific spindle pole body integrity. Jin Y, et al. Genetics, 2002 Mar. PMID 11901107, Free PMC Article
    3. Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. Iwaki T, et al. Microbiology (Reading), 2007 Aug. PMID 17660439, Free PMC Article
    4. Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways. Das J, et al. Sci Signal, 2013 May 21. PMID 23695164, Free PMC Article
    5. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dot2, the fission yeast homolog of the human transcription factor EAP30, negatively regulates meiotic spindle pole body maturation. [dot2]
      Title: The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESCRT II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    NOT is_active_in meiotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ESCRT II complex subunit Dot2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1245920..1247116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021413.2 → NP_595503.1  ESCRT II complex subunit Dot2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595503.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94663
      Conserved Domains (1) summary
      pfam04157
      Location:6 → 225
      EAP30; EAP30/Vps36 family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous