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    rhb1 Rheb GTPase Rhb1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540853, updated on 13-Mar-2024

    Summary

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    Gene symbol
    rhb1
    Gene description
    Rheb GTPase Rhb1
    Primary source
    PomBase:SPBC428.16c
    Locus tag
    SPBC428.16c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rhb1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (473670..474573, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein Neighboring gene putative 1-acylglycerol-3-phosphate acyltransferase Neighboring gene Sid2-Mob1 kinase complex regulatory subunit Mob1 Neighboring gene miscRNA Neighboring gene putative Obg-like ATPase Neighboring gene WAPL family protein Neighboring gene replication licensing factor Cdt1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. van Slegtenhorst M, et al. J Biol Chem, 2004 Mar 26. PMID 14718525
    2. The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast. Aspuria PJ, et al. Mol Genet Genomics, 2008 May. PMID 18219492, Free PMC Article
    3. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. Urano J, et al. Proc Natl Acad Sci U S A, 2007 Feb 27. PMID 17360675, Free PMC Article
    4. Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Urano J, et al. Mol Microbiol, 2005 Nov. PMID 16262791
    5. Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase. Murai T, et al. Genetics, 2009 Oct. PMID 19620394, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies postulate that the signaling cascade may branch below Rhb1 or Tor2 and regulate the amino acid uptake and response to nitrogen starvation independently.
      Title: Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
    2. A crucial link between Tsc/Rheb signaling and the regulation of the basic amino acid permease in fission yeast.
      Title: The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast.
    3. identifcation of hyperactivating mutations in Rhb1; demonstrated that Rhb1 interacts with Tor2
      Title: Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of L-arginine import across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rheb GTPase Rhb1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      473670..474573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021101.2 → NP_595194.1  Rheb GTPase Rhb1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595194.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94363
      Conserved Domains (2) summary
      smart00010
      Location:5 → 170
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04137
      Location:6 → 184
      RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase
    Nucleotide Protein
    Heading Accession and Version

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