mcs6 cyclin-dependent protein kinase/CDK-activating kinase Mcs6 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Go to the top of the page Help

Gene symbol: mcs6
Gene description: cyclin-dependent protein kinase/CDK-activating kinase Mcs6
Locus tag: SPBC19F8.07
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: cdk7; crk1; mop1
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See mcs6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_003423.3 (3243309..3244568)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdk7 kinase modulates transcription through its RNA Pol II C-terminal domain kinase activity and also through the Cdc2-activating kinase activity.
Title: Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.
identified a novel Skp1 association with Mcs2 and Pmh1 that appears to be SCF-independent both in respect to subunit composition and absence of SCF dependent proteolysis
Title: Mcs2 and a novel CAK subunit Pmh1 associate with Skp1 in fission yeast.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity	EXP Inferred from Experiment more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	HDA more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH holo complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIIK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIK complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cyclin-dependent protein kinase/CDK-activating kinase Mcs6

NP_596349.1

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

3243309..3244568

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001022269.2 → NP_596349.1 cyclin-dependent protein kinase/CDK-activating kinase Mcs6 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_596349.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q12126

Conserved Domains (2) summary

cd07841
Location:11 → 305

STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

pfam00069
Location:11 → 292

Pkinase; Protein kinase domain