Sdk2 sidekick cell adhesion molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdk2provided by MGI
Official Full Name: sidekick cell adhesion molecule 2provided by MGI
Primary source: MGI:MGI:2443847
See related: Ensembl:ENSMUSG00000041592 AllianceGenome:MGI:2443847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sdk-2; mKIAA1514; 4632412F08Rik; 5330435L01Rik
Summary: Involved in homophilic cell adhesion via plasma membrane adhesion molecules; retina morphogenesis in camera-type eye; and synapse assembly. Located in synapse. Is expressed in several structures, including brain; long bone; metanephros; retina nuclear layer; and ventral grey horn. Orthologous to human SDK2 (sidekick cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 3.2), frontal lobe adult (RPKM 1.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 79.3 cM

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (113667200..113957855, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (113776374..114067029, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that the Ig-like domains and the fibronectin III (FnIII) domains of Sidekicks play different roles in cell adhesion. The Ig-like domains mediate the homophilic transinteractions bridging adjacent cells, while the FnIII domains interact with membranes, resulting in a tight adhesion interface between cells
Title: Architecture of cell-cell adhesion mediated by sidekicks.
Here the authors report crystal structures of Sdk1 and Sdk2 ectodomain regions, revealing similar homodimers mediated by the four N-terminal immunoglobulin domains (Ig1-4), arranged in a horseshoe conformation.
Title: Molecular basis of sidekick-mediated cell-cell adhesion and specificity.
the Sdk2-specified synapse is essential for visual responses of W3B retinal ganglion cells
Title: Sidekick 2 directs formation of a retinal circuit that detects differential motion.
These results demonstrate that localization and function of Sidekick-2 require its incorporation into a MAGI-containing synaptic scaffold.
Title: Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins.
results establish that the first and second immunoglobulin domains of sidekick-1 and -2 are necessary and sufficient to mediate and target homophilic adhesion
Title: Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sdk1 (e-PCR), detects polymorphism
- UniSTS:525643

Sdk2 (e-PCR), detects polymorphism
- UniSTS:525644

D11Mit128 (e-PCR), detects polymorphism
- UniSTS:126318

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in camera-type eye photoreceptor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in retina layer formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein sidekick-2

Names: sidekick 2; sidekick homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172800.3 → NP_766388.2 protein sidekick-2 precursor

See identical proteins and their annotated locations for NP_766388.2

Status: VALIDATED

Source sequence(s)

AL603706, AL627323, AL663117

Consensus CDS

CCDS25605.1

UniProtKB/Swiss-Prot

Q3TTK1, Q5U5W7, Q6V4S5, Q6ZPP2

Related

ENSMUSP00000038972.8, ENSMUST00000041627.14

Conserved Domains (6) summary

cd00096
Location:330 → 398

Ig; Immunoglobulin domain

smart00408
Location:237 → 290

IGc2; Immunoglobulin C-2 Type

smart00410
Location:506 → 590

IG_like; Immunoglobulin like

cd00063
Location:1630 → 1723

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:406 → 496

I-set; Immunoglobulin I-set domain

cl11960
Location:420 → 496

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

113667200..113957855 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533253.5 → XP_006533316.1 protein sidekick-2 isoform X1

Conserved Domains (5) summary

cd00063
Location:1611 → 1704

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:237 → 290

Ig; Immunoglobulin domain

pfam07679
Location:406 → 496

I-set; Immunoglobulin I-set domain

pfam13927
Location:30 → 99

Ig_3; Immunoglobulin domain

cl11960
Location:312 → 401

Ig; Immunoglobulin domain
XM_006533255.4 → XP_006533318.1 protein sidekick-2 isoform X3

Conserved Domains (4) summary

cd00063
Location:1472 → 1565

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:79 → 132

Ig; Immunoglobulin domain

pfam07679
Location:248 → 338

I-set; Immunoglobulin I-set domain

cl11960
Location:154 → 243

Ig; Immunoglobulin domain
XM_006533254.5 → XP_006533317.1 protein sidekick-2 isoform X2

Conserved Domains (4) summary

cd00063
Location:1506 → 1599

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:113 → 166

Ig; Immunoglobulin domain

pfam07679
Location:282 → 372

I-set; Immunoglobulin I-set domain

cl11960
Location:188 → 277

Ig; Immunoglobulin domain