Cd300e CD300E molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd300eprovided by MGI
Official Full Name: CD300E moleculeprovided by MGI
Primary source: MGI:MGI:2387602
See related: Ensembl:ENSMUSG00000048498 AllianceGenome:MGI:2387602
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLM2; TREM5; Cd300le
Summary: Predicted to enable transmembrane signaling receptor activity. Predicted to act upstream of or within immune system process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in ductus deferens; epididymis; and esophagus. Orthologous to human CD300E (CD300e molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 2.1), lung adult (RPKM 1.0) and 10 other tissues See more
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Genomic context

Location:: 11 E2; 11 80.58 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114942743..114957502, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115051917..115066676, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12)
Title: The CD300e molecule in mice is an immune-activating receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CMRF35-like molecule 2

Names: CD300 antigen like family member E; CD300e antigen; CMRF-35-like molecule-1; immune receptor expressed on myeloid cells 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172050.3 → NP_742047.1 CMRF35-like molecule 2 precursor

See identical proteins and their annotated locations for NP_742047.1

Status: VALIDATED

Source sequence(s)

AL607025

Consensus CDS

CCDS25618.1

UniProtKB/Swiss-Prot

Q8K249

Conserved Domains (1) summary

cd05716
Location:24 → 126

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

114942743..114957502 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533073.1 → XP_006533136.1 CMRF35-like molecule 2 isoform X1

See identical proteins and their annotated locations for XP_006533136.1

UniProtKB/Swiss-Prot

Q8K249

Related

ENSMUSP00000054883.8, ENSMUST00000062787.9

Conserved Domains (1) summary

cd05716
Location:24 → 126

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
XM_006533074.1 → XP_006533137.1 CMRF35-like molecule 2 isoform X1

See identical proteins and their annotated locations for XP_006533137.1

UniProtKB/Swiss-Prot

Q8K249

Conserved Domains (1) summary

cd05716
Location:24 → 126

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains