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    St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ Mus musculus (house mouse) ]

    Gene ID: 20443, updated on 5-Mar-2024

    Summary

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    Official Symbol
    St3gal4provided by MGI
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 4provided by MGI
    Primary source
    MGI:MGI:1316743
    See related
    Ensembl:ENSMUSG00000032038 AllianceGenome:MGI:1316743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat4c; SIAT4-C; ST3GalIV; ST3Gal IV
    Summary
    Enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity and beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in positive regulation of blood coagulation and positive regulation of leukocyte tethering or rolling. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Orthologous to human ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 32.7), small intestine adult (RPKM 23.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St3gal4 in Genome Data Viewer
    Location:
    9 A4; 9 19.36 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (34957872..35028160, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35046576..35116864, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 3 Neighboring gene predicted gene, 33561 Neighboring gene kirre like nephrin family adhesion molecule 3, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E3822 Neighboring gene STARR-seq mESC enhancer starr_23759 Neighboring gene predicted gene, 51705 Neighboring gene RIKEN cDNA 4930581F22 gene Neighboring gene STARR-seq mESC enhancer starr_23763 Neighboring gene predicted gene, 57537 Neighboring gene predicted gene, 24262 Neighboring gene decapping enzyme, scavenger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exposure to 3'Sialyllactose-Poor Milk during Lactation Impairs Cognitive Capabilities in Adulthood. Pisa E, et al. Nutrients, 2021 Nov 23. PMID 34959743, Free PMC Article
    2. Urinary volatilome analysis in a mouse model of anxiety and depression. Fujita A, et al. PLoS One, 2020. PMID 32084196, Free PMC Article
    3. Sialic acid catabolism drives intestinal inflammation and microbial dysbiosis in mice. Huang YL, et al. Nat Commun, 2015 Aug 25. PMID 26303108, Free PMC Article
    4. Differential effects of dietary oils on emotional and cognitive behaviors. Kato K. PLoS One, 2015. PMID 25799588, Free PMC Article
    5. Reduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly. Ednie AR, et al. J Biol Chem, 2015 Jan 30. PMID 25525262, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
      Title: Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
    2. The results of this study indicated that ST3Gal IV is a key molecule in the mechanisms underlying anxiety - a side effect of TLE - and may therefore also be an effective target for treating epilepsy, acting through the same circuits.
      Title: Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.
    3. St3Gal4-deficient myeloid cells had less binding of Ccl5 and impaired Ccl5-triggered integrin activation. St3Gal4 deficiency reduced the size, stage, and inflammatory cell content of atherosclerotic lesions in Apoe(-/-) mice on high-fat diet.
      Title: Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication.
    4. St3gal4, potentially involved in antithrombin sialylation, was 85% lower in neonates in comparison with adults
      Title: Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a.
    5. Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction.
      Title: Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction.
    6. Coordinated participation of both ST3Gal-VI and ST3Gal-IV in the synthesis of functional selectin ligands.
      Title: Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands.
    7. Data show that the sialyltransferase enzymes St6gal1 and St3gal4 are responsible for the production of sialyllactose in mouse milk.
      Title: Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization.
    8. Sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo.
      Title: Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation.
    9. operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands
      Title: Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands.
    10. was found to play a role in regulating synthesis of selectin ligands and in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
      Title: Sialyltransferase specificity in selectin ligand formation.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of leukocyte tethering or rolling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
    Names
    N-acetyllactosaminide alpha-2,3-sialyltransferase
    alpha 2,3-ST 4
    alpha 2,3-sialyltransferase IV
    beta-galactoside alpha-2,3-sialyltransferase 4
    gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
    gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase
    sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)
    sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)
    NP_033204.2
    XP_006510171.1
    XP_006510172.1
    XP_006510173.1
    XP_006510174.1
    XP_006510175.1
    XP_011240731.1
    XP_011240735.1
    XP_036010638.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009178.4 → NP_033204.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

      See identical proteins and their annotated locations for NP_033204.2

      Status: VALIDATED

      Source sequence(s)
      AC140448, AI385650, BC050773
      Consensus CDS
      CCDS22956.1
      UniProtKB/Swiss-Prot
      P97354, Q61325, Q91Y74
      UniProtKB/TrEMBL
      Q921R5
      Related
      ENSMUSP00000034537.7, ENSMUST00000034537.8
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      34957872..35028160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154745.1 → XP_036010638.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

      UniProtKB/Swiss-Prot
      P97354, Q61325, Q91Y74
      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006510108.2 → XP_006510171.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X2

      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:147 → 371
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_006510109.5 → XP_006510172.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X3

      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:144 → 368
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_006510110.5 → XP_006510173.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X4

      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:141 → 365
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_011242429.4 → XP_011240731.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X7

      See identical proteins and their annotated locations for XP_011240731.1

      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:139 → 363
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_006510112.5 → XP_006510175.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X6

      See identical proteins and their annotated locations for XP_006510175.1

      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:139 → 363
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_011242433.2 → XP_011240735.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

      See identical proteins and their annotated locations for XP_011240735.1

      UniProtKB/Swiss-Prot
      P97354, Q61325, Q91Y74
      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:107 → 331
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. XM_006510111.4 → XP_006510174.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X5

      See identical proteins and their annotated locations for XP_006510174.1

      UniProtKB/TrEMBL
      Q921R5
      Conserved Domains (1) summary
      pfam00777
      Location:139 → 363
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Y74.1 GenPept UniProtKB/Swiss-Prot:Q91Y74

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