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    F43B10.1 EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181721, updated on 23-Nov-2023

    Summary

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    Gene symbol
    F43B10.1
    Gene description
    EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00018373
    Locus tag
    CELE_F43B10.1
    See related
    AllianceGenome:WB:WBGene00018373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Is expressed in body wall musculature; non-striated muscle; pharynx; and seam cell. Orthologous to several human genes including PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (16637633..16662823, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Lipid-binding serum glycoprotein C-terminal domain-containing protein Neighboring gene tRNA-His Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNA polymerase II-associated factor 1 homolog Neighboring gene Spore coat protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. Anders KR, et al. EMBO J, 2003 Feb 3. PMID 12554664, Free PMC Article
    2. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that the role of SMG-5 is to direct protein phosphatase 2A to its SMG-2 substrate
      Title: SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing protein
    NP_001257276.1
    • Confirmed by transcript evidence
    NP_001257277.1
    • Confirmed by transcript evidence
    NP_001335559.1
    • Partially confirmed by transcript evidence
    NP_001335569.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      16637633..16662823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348608.3 → NP_001335559.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYT5
      Conserved Domains (2) summary
      pfam13499
      Location:467 → 566
      EF-hand_7; EF-hand domain pair
      cl26464
      Location:153 → 308
      Atrophin-1; Atrophin-1 family

    2. NM_001348609.4 → NP_001335569.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYW5
      Conserved Domains (2) summary
      pfam13499
      Location:1096 → 1195
      EF-hand_7; EF-hand domain pair
      cl26464
      Location:473 → 937
      Atrophin-1; Atrophin-1 family

    3. NM_001270348.4 → NP_001257277.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17744
      Conserved Domains (1) summary
      pfam13499
      Location:331 → 427
      EF-hand_7; EF-hand domain pair

    4. NM_001270347.4 → NP_001257276.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8W3X6
      Conserved Domains (1) summary
      pfam13499
      Location:379 → 475
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version

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