acn-1 Inactive angiotensin-converting enzyme-related protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: acn-1
Gene description: Inactive angiotensin-converting enzyme-related protein
Primary source: WormBase:WBGene00000039
Locus tag: CELE_C42D8.5
See related: AllianceGenome:WB:WBGene00000039
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metallopeptidase activity. Involved in ecdysis, collagen and cuticulin-based cuticle and nematode male tail tip morphogenesis. Acts upstream of or within with a negative effect on plasma membrane fusion. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in excretory gland cell; hypodermis; vulva; and in male. Human ortholog(s) of this gene implicated in several diseases, including Coronavirus infectious disease (multiple); artery disease (multiple); autoimmune disease (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to several human genes including ACE2 (angiotensin converting enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See acn-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (5092481..5097067, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

acn-1 genetically interacts with the let-7 microRNA and other heterochronic genes during C. elegans development.
Title: acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.
Acn-1 is a gene that influences C. elegans aging and life span.
Title: Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span.
ACN-1 has an essential role in molting and morphogenesis of Caenorhabditis elegans
Title: An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C42D8.5 (e-PCR)
- UniSTS:308758

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
NOT enables metallopeptidase activity	IKR Inferred from Key Residues more info	PubMed
enables peptidyl-dipeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ecdysis, collagen and cuticulin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_negative_effect plasma membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
NOT involved_in proteolysis	IKR Inferred from Key Residues more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Inactive angiotensin-converting enzyme-related protein

NP_001024453.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5092481..5097067 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029282.7 → NP_001024453.1 Inactive angiotensin-converting enzyme-related protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18581, Q65ZH6

Conserved Domains (2) summary

pfam01401
Location:175 → 764

Peptidase_M2; Angiotensin-converting enzyme

pfam01683
Location:794 → 833

EB; EB module