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    ufc-1 Ubiquitin-fold modifier-conjugating enzyme 1 [ Caenorhabditis elegans ]

    Gene ID: 176313, updated on 23-Nov-2023

    Summary

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    Gene symbol
    ufc-1
    Gene description
    Ubiquitin-fold modifier-conjugating enzyme 1
    Primary source
    WormBase:WBGene00008041
    Locus tag
    CELE_C40H1.6
    See related
    AllianceGenome:WB:WBGene00008041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin conjugating enzyme binding activity. Predicted to be involved in protein K69-linked ufmylation. Located in striated muscle dense body. Is expressed in intestine and neurons. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (9331514..9332284)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transthyretin-like protein 5 Neighboring gene ncRNA Neighboring gene Putative fatty acid elongation protein 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans. Hertel P, et al. J Biol Chem, 2013 Apr 12. PMID 23449979, Free PMC Article
    2. An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism. Chen C, et al. PLoS Genet, 2014 Mar. PMID 24603482, Free PMC Article
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UFM1 conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UFM1 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein K69-linked ufmylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ufmylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Ubiquitin-fold modifier-conjugating enzyme 1
    NP_499055.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9331514..9332284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066654.7 → NP_499055.1  Ubiquitin-fold modifier-conjugating enzyme 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499055.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03598
      Conserved Domains (1) summary
      pfam08694
      Location:5 → 159
      UFC1; Ubiquitin-fold modifier-conjugating enzyme 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03598.1

    Gene LinkOut

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