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    cic-1 Cyclin-C [ Caenorhabditis elegans ]

    Gene ID: 175357, updated on 23-Nov-2023

    Summary

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    Gene symbol
    cic-1
    Gene description
    Cyclin-C
    Primary source
    WormBase:WBGene00000506
    Locus tag
    CELE_H14E04.5
    See related
    AllianceGenome:WB:WBGene00000506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Predicted to be active in nucleus. Is expressed in neurons. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (2394325..2401221, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Nucleoside phosphorylase domain-containing protein Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sterol 4-C-methyltransferase strm-1 Neighboring gene 39S ribosomal protein L30, mitochondrial Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metazoan operons accelerate recovery from growth-arrested states. Zaslaver A, et al. Cell, 2011 Jun 10. PMID 21663799, Free PMC Article
    2. The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans. Grants JM, et al. Genetics, 2016 Feb. PMID 26715664, Free PMC Article
    3. Identification of genes interacting with rnt-1 through large-scale RNAi screening in Caenorhabditis elegans. Lee K, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979934, Free PMC Article
    4. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
    5. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-C
    NP_497548.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2394325..2401221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065147.7 → NP_497548.2  Cyclin-C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497548.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TYP2
      Conserved Domains (2) summary
      cd00043
      Location:64 → 108
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl00050
      Location:162 → 261
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TYP2.2

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