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    tomm-40 Mitochondrial import receptor subunit TOM40 homolog [ Caenorhabditis elegans ]

    Gene ID: 174431, updated on 23-Nov-2023

    Summary

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    Gene symbol
    tomm-40
    Gene description
    Mitochondrial import receptor subunit TOM40 homolog
    Primary source
    WormBase:WBGene00007686
    Locus tag
    CELE_C18E9.6
    See related
    AllianceGenome:WB:WBGene00007686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix. Located in mitochondrial membrane. Is expressed in several structures, including hypodermis; intestine; nervous system; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to several human genes including TOMM40 (translocase of outer mitochondrial membrane 40). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (8971965..8973566, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Translocation protein SEC62 Neighboring gene SUZ domain-containing protein;Suppressor of zyg-1 protein 20 Neighboring gene uncharacterized protein Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial function is required for secretion of DAF-28/insulin in C. elegans. Billing O, et al. PLoS One, 2011 Jan 17. PMID 21264209, Free PMC Article
    2. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Nargund AM, et al. Science, 2012 Aug 3. PMID 22700657, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial import receptor subunit TOM40 homolog
    NP_495912.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8971965..8973566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063511.7 → NP_495912.1  Mitochondrial import receptor subunit TOM40 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18090
      Conserved Domains (1) summary
      cd07305
      Location:16 → 301
      Porin3_Tom40; Translocase of outer mitochondrial membrane 40 (Tom40)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18090.1

    Gene LinkOut

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