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    fasn-1 Carrier domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172715, updated on 11-Apr-2024

    Summary

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    Gene symbol
    fasn-1
    Gene description
    Carrier domain-containing protein
    Primary source
    WormBase:WBGene00009342
    Locus tag
    CELE_F32H2.5
    See related
    AllianceGenome:WB:WBGene00009342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid synthase activity. Predicted to be involved in fatty acid biosynthetic process. Is expressed in excretory duct; hermaphrodite gonad; hypodermis; intestine; and neurons. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (8975366..8986540, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene SRCR domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The fasn-1(g14ts) allele is a Gly1830Arg missense mutation in C. elegans FASN-1. Bai X, et al. MicroPubl Biol, 2020 May 5. PMID 32550489, Free PMC Article
    2. The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis. Lee KZ, et al. Virulence, 2010 May-Jun. PMID 21178429, Free PMC Article
    3. Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development. Weaver BP, et al. Dev Cell, 2020 May 4. PMID 32302544, Free PMC Article
    4. Piceatannol Reduces Fat Accumulation in Caenorhabditis elegans. Shen P, et al. J Med Food, 2017 Sep. PMID 28514198, Free PMC Article
    5. A potential role for fatty acid biosynthesis genes during molting and cuticle formation in Caenorhabditis elegans. Li Y, et al. BMB Rep, 2011 Apr. PMID 21524356

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteolytic activation of fatty acid synthase signals pan-stress resolution.
      Title: Proteolytic activation of fatty acid synthase signals pan-stress resolution.
    2. Fatty acid synthase (FAS) gene, encoding for a key enzyme involved in the biogenesis of membrane lipids in rapidly proliferating cells, is a conserved target of the p53 family throughout the evolution.
      Title: The fatty acid synthase gene is a conserved p53 family target from worm to human.
    3. Fasn-1 regulates antimicrobial peptide nlp-29 expression in a WNK-1 and gck-3 dependent manner.
      Title: The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [acyl-carrier-protein] S-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-[ACP] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocarboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Carrier domain-containing protein
    NP_492417.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8975366..8986540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060016.8 → NP_492417.2  Carrier domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492417.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91871
      Conserved Domains (9) summary
      cd08954
      Location:1968 → 2204
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00829
      Location:1654 → 1946
      PKS_ER; Enoylreductase
      cd00833
      Location:38 → 440
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:398 → 507
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      pfam00550
      Location:2219 → 2284
      PP-binding; Phosphopantetheine attachment site
      cl00509
      Location:892 → 1104
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:533 → 852
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:1406 → 1602
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:2385 → 2444
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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