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    pdi-3 Protein disulfide-isomerase [ Caenorhabditis elegans ]

    Gene ID: 172433, updated on 23-Nov-2023

    Summary

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    Gene symbol
    pdi-3
    Gene description
    Protein disulfide-isomerase
    Primary source
    WormBase:WBGene00003964
    Locus tag
    CELE_H06O01.1
    See related
    AllianceGenome:WB:WBGene00003964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including cellular protein modification process; male anatomical structure morphogenesis; and oviposition. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (7015912..7020797, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein ctg-1 Neighboring gene DNA helicase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ubiquilin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thioredoxin motif of Caenorhabditis elegans PDI-3 provides Cys and His catalytic residues for transglutaminase activity. Blaskó B, et al. Biochem Biophys Res Commun, 2003 Apr 18. PMID 12684055
    2. Molecular cloning and expression of Caenorhabditis elegans ERp57-homologue with transglutaminase activity. Natsuka S, et al. J Biochem, 2001 Dec. PMID 11726271
    3. DNA nanodevices map enzymatic activity in organelles. Dan K, et al. Nat Nanotechnol, 2019 Mar. PMID 30742135, Free PMC Article
    4. Protein disulfide isomerases from C. elegans are equally efficient at thiol-disulfide exchange in simple peptide-based systems but show differences in reactivity towards protein substrates. Karala AR, et al. Antioxid Redox Signal, 2007 Nov. PMID 17711389
    5. Expression of hepatitis B virus surface antigens induces defective gonad phenotypes in Caenorhabditis elegans. Chen YY, et al. World J Virol, 2017 Feb 12. PMID 28239568, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pdi-1, pdi-2, and pdi-3 have comparable kinetic properties in catalyzing thiol-disulfide exchange reactions in two simple peptide-based assays. However, the three enzymes exhibited clear differences in their reactivity towards protein substrates.
      Title: Protein disulfide isomerases from C. elegans are equally efficient at thiol-disulfide exchange in simple peptide-based systems but show differences in reactivity towards protein substrates.
    2. Thioredoxin motif of PDI-3 provides Cys and His catalytic residues for transglutaminase activity.
      Title: Thioredoxin motif of Caenorhabditis elegans PDI-3 provides Cys and His catalytic residues for transglutaminase activity.
    3. determination of disulfide isomerase and transglutaminase-like cross linking activity and involvement in maintaining body morphology.
      Title: The Caenorhabditis elegans ERp60 homolog protein disulfide isomerase-3 has disulfide isomerase and transglutaminase-like cross-linking activity and is involved in the maintenance of body morphology.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in body morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in collagen and cuticulin-based cuticle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail mating organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein deglutathionylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein disulfide-isomerase
    NP_491995.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7015912..7020797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059594.9 → NP_491995.1  Protein disulfide-isomerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ED07
      Conserved Domains (5) summary
      cd02995
      Location:364 → 465
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03069
      Location:130 → 232
      PDI_b_ERp57; PDIb family, ERp57 subfamily, first redox inactive TRX-like domain b; ERp57 (or ERp60) exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting ...
      cd03073
      Location:236 → 344
      PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
      TIGR01130
      Location:21 → 477
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:26 → 127
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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