Opn1mw opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Opn1mwprovided by MGI
Official Full Name: opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)provided by MGI
Primary source: MGI:MGI:1097692
See related: Ensembl:ENSMUSG00000031394 AllianceGenome:MGI:1097692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gcp; Rsvp; Opn1lw; ML-opsin
Summary: Predicted to enable G protein-coupled photoreceptor activity and identical protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to act upstream of or within protein-chromophore linkage and signal transduction. Located in photoreceptor outer segment. Is expressed in eye; photoreceptor layer; photoreceptor layer outer segment; retina; and retina outer nuclear layer. Used to study blue cone monochromacy. Human ortholog(s) of this gene implicated in blue cone monochromacy and red color blindness. Orthologous to several human genes including OPN1LW (opsin 1, long wave sensitive) and OPN1MW2 (opsin 1, medium wave sensitive 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X; X A7.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (73171072..73194362)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (74127466..74150756)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.
Title: Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.
quantitative FRET analysis in acutely isolated cone OS revealed that the cone degeneration-causing V268I mutation in peripherin-2 selectively reduced binding to M-opsin without affecting the peripherin-2 interaction to S-opsin or rhodopsin
Title: Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.
Here, the creation and validation of two lines of genetically engineered mice that can be used to study disease-causing variants of human L/M-opsins, in vivo, are described.
Title: S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.
Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII.
Title: Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.
ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin or S-cone opsin
Title: Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.
alpha transducin and opsin have roles in mouse photoreceptor cell responses to light and dark
Title: Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.
results show that UV-opsin suppression successively ceases in presence of the M-opsin activating background light, which implies that cone light adaptation is controlled at the opsin stage, before activation of transducin.
Title: Co-expression of murine opsins facilitates identifying the site of cone adaptation.
Thus, the three types of mouse opsin appear distinctive in the degree to which their bleached, unregenerated opsins generate "dark light."
Title: Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

stSG603914 (e-PCR)
- UniSTS:447337

Opn1mw (e-PCR), detects polymorphism
- UniSTS:536456

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables photoreceptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: medium-wave-sensitive opsin 1

Names: G/R opsin; MWS opsin; R/G opsin; green LWS photopigment; green cone photoreceptor pigment; green long wavelength sensitive cone opsin; green-sensitive opsin; medium wavelength-sensitive cone opsin; midwavelength sensitive opsin; opsin 1 (cone pigments), long-wave-sensitive; red sensitive visual pigment

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.