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    Pou6f1 POU class 6 homeobox 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116545, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pou6f1provided by RGD
    Official Full Name
    POU class 6 homeobox 1provided by RGD
    Primary source
    RGD:620615
    See related
    Ensembl:ENSRNOG00000004595 Ensembl:ENSRNOG00000070769 AllianceGenome:RGD:620615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Brn5
    Summary
    Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in actin cytoskeleton and nuclear body. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 35.1), Kidney (RPKM 25.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133556506..133580004, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131677719..131700869, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142201614..142225256, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2 Neighboring gene transcription factor CP2 Neighboring gene uncharacterized LOC120093736 Neighboring gene uncharacterized LOC134479579 Neighboring gene uncharacterized LOC134479580

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transgenic Schwann cells overexpressing POU6F1 promote sciatic nerve regeneration within acellular nerve allografts. Li WY, et al. J Neural Eng, 2022 Nov 10. PMID 36317259
    2. Expression of the POU transcription factor Brn-5 is an early event in the terminal differentiation of CNS neurons. Cui H, et al. J Neurosci Res, 1998 Jun 15. PMID 9669311
    3. Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex. Andersen B, et al. J Biol Chem, 1993 Nov 5. PMID 7901208
    4. Identification of novel DNA binding sites recognized by the transcription factor mPOU (POU6F1). Wey E, et al. Biochem Biophys Res Commun, 1996 Mar 18. PMID 8645295
    5. Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL. Toda K, et al. Mol Cell Endocrinol, 2008 Jan 2. PMID 17933456

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transgenic Schwann cells overexpressing POU6F1 promote sciatic nerve regeneration within acellular nerve allografts.
      Title: Transgenic Schwann cells overexpressing POU6F1 promote sciatic nerve regeneration within acellular nerve allografts.
    2. Brn-5 enhances prolactin gene expression directly in association with Pit-1 and CREB-binding protein, and indirectly via the activation of Pit-1 gene expression.
      Title: Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 6, transcription factor 1
    Names
    brain-5
    brain-specific homeobox/POU domain protein 5
    brn-5 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105746.1 → NP_001099216.1  POU domain, class 6, transcription factor 1

      See identical proteins and their annotated locations for NP_001099216.1

      Status: VALIDATED

      Source sequence(s)
      CH474035
      UniProtKB/Swiss-Prot
      P56223
      UniProtKB/TrEMBL
      A6KCK3
      Related
      ENSRNOP00000006095.4, ENSRNOT00000006095.7
      Conserved Domains (3) summary
      PRK14950
      Location:23 → 155
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam00046
      Location:237 → 291
      Homeobox; Homeobox domain
      cl22952
      Location:139 → 213
      Pou; Pou domain - N-terminal to homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133556506..133580004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078246.2 → XP_038934174.1  POU domain, class 6, transcription factor 1 isoform X3

      Conserved Domains (3) summary
      smart00352
      Location:449 → 523
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:41 → 426
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:547 → 601
      Homeobox; Homeobox domain

    2. XM_039078243.2 → XP_038934171.1  POU domain, class 6, transcription factor 1 isoform X1

      Conserved Domains (3) summary
      smart00352
      Location:453 → 527
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:45 → 430
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:551 → 605
      Homeobox; Homeobox domain

    3. XM_039078244.2 → XP_038934172.1  POU domain, class 6, transcription factor 1 isoform X1

      Conserved Domains (3) summary
      smart00352
      Location:453 → 527
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:45 → 430
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:551 → 605
      Homeobox; Homeobox domain

    4. XM_039078245.2 → XP_038934173.1  POU domain, class 6, transcription factor 1 isoform X2

      Conserved Domains (3) summary
      smart00352
      Location:452 → 526
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:52 → 429
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:550 → 604
      Homeobox; Homeobox domain

    5. XM_063262865.1 → XP_063118935.1  POU domain, class 6, transcription factor 1 isoform X3

    6. XM_063262864.1 → XP_063118934.1  POU domain, class 6, transcription factor 1 isoform X1

    7. XM_039078248.2 → XP_038934176.1  POU domain, class 6, transcription factor 1 isoform X6

      Conserved Domains (3) summary
      smart00352
      Location:415 → 489
      POU; Found in Pit-Oct-Unc transcription factors
      PHA03247
      Location:49 → 392
      PHA03247; large tegument protein UL36; Provisional
      pfam00046
      Location:513 → 567
      Homeobox; Homeobox domain

    8. XM_063262866.1 → XP_063118936.1  POU domain, class 6, transcription factor 1 isoform X7

    9. XM_017594569.3 → XP_017450058.1  POU domain, class 6, transcription factor 1 isoform X5

      UniProtKB/Swiss-Prot
      P56223
      UniProtKB/TrEMBL
      A6KCK3
      Conserved Domains (3) summary
      PRK14950
      Location:23 → 155
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      pfam00046
      Location:237 → 291
      Homeobox; Homeobox domain
      cl22952
      Location:139 → 213
      Pou; Pou domain - N-terminal to homeobox domain

    10. XM_039078247.2 → XP_038934175.1  POU domain, class 6, transcription factor 1 isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:63 → 309
      PHA03247; large tegument protein UL36; Provisional
      PRK07994
      Location:175 → 277
      PRK07994; DNA polymerase III subunits gamma and tau; Validated

    RNA

    1. XR_010052928.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56223.1 GenPept UniProtKB/Swiss-Prot:P56223

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