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    Dhx32 DEAH-box helicase 32 (putative) [ Mus musculus (house mouse) ]

    Gene ID: 101437, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Dhx32provided by MGI
    Official Full Name
    DEAH-box helicase 32 (putative)provided by MGI
    Primary source
    MGI:MGI:2141813
    See related
    Ensembl:ENSMUSG00000030986 AllianceGenome:MGI:2141813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx32; muDDX32; 4732469F02Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be located in mitochondrion and nucleus. Predicted to be part of spliceosomal complex. Orthologous to human DHX32 (DEAH-box helicase 32 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 23.6), placenta adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 F3; 7 77.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133322671..133384514, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133720935..133782785, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4982 Neighboring gene STARR-positive B cell enhancer ABC_E10481 Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene STARR-seq mESC enhancer starr_20333 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene predicted gene 15483 Neighboring gene fibronectin type 3 and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_20336 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene predicted gene, 51500 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 39103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of murine Dhx32. Alli Z, et al. Exp Mol Pathol, 2007 Aug. PMID 17239371
    2. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. Abdelhaleem M. Leuk Res, 2002 Oct. PMID 12163057
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 3110079L04Rik, 4732469F02Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
    DEAH (Asp-Glu-Ala-His) box polypeptide 32
    DEAH box protein 32
    helicase DDX32
    NP_001272959.2
    NP_001272960.2
    NP_001272961.1
    NP_001344614.2
    NP_001390352.1
    NP_001390353.1
    NP_001390354.1
    NP_598702.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286030.2 → NP_001272959.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
      Source sequence(s)
      AC127348
      Consensus CDS
      CCDS21936.1
      UniProtKB/Swiss-Prot
      Q3TFU4, Q8BZS9, Q8VH39, Q922N6
      Related
      ENSMUST00000140593.9

    2. NM_001286031.2 → NP_001272960.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
      Source sequence(s)
      AC127348
      Consensus CDS
      CCDS21936.1
      UniProtKB/Swiss-Prot
      Q3TFU4, Q8BZS9, Q8VH39, Q922N6
      Related
      ENSMUSP00000066067.3, ENSMUST00000063669.8

    3. NM_001286032.2 → NP_001272961.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform b

      See identical proteins and their annotated locations for NP_001272961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks the exon containing the translation start codon and therefore uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC127348
      Consensus CDS
      CCDS72060.1
      UniProtKB/TrEMBL
      D3Z4E3
      Related
      ENSMUSP00000101745.2, ENSMUST00000106139.8
      Conserved Domains (3) summary
      smart00847
      Location:332 → 416
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:1 → 547
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:457 → 564
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    4. NM_001357685.2 → NP_001344614.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter when compared to isoform a. Variants 5 and 6 encode the same isoform (c).
      Source sequence(s)
      AC127348

    5. NM_001403423.1 → NP_001390352.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: Variants 5 and 6 encode the same isoform (c).
      Source sequence(s)
      AC127348

    6. NM_001403424.1 → NP_001390353.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
      Source sequence(s)
      AC127348
      UniProtKB/Swiss-Prot
      Q3TFU4, Q8BZS9, Q8VH39, Q922N6

    7. NM_001403425.1 → NP_001390354.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
      Source sequence(s)
      AC127348
      UniProtKB/Swiss-Prot
      Q3TFU4, Q8BZS9, Q8VH39, Q922N6

    8. NM_133941.3 → NP_598702.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
      Source sequence(s)
      AC127348
      Consensus CDS
      CCDS21936.1
      UniProtKB/Swiss-Prot
      Q3TFU4, Q8BZS9, Q8VH39, Q922N6
      Related
      ENSMUSP00000033290.7, ENSMUST00000033290.12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      133322671..133384514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZS9.2 GenPept UniProtKB/Swiss-Prot:Q8BZS9

    Gene LinkOut

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