gpr84 G protein-coupled receptor 84 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gpr84provided by ZNC
Official Full Name: G protein-coupled receptor 84provided by ZNC
Primary source: ZFIN:ZDB-GENE-070928-33
See related: Ensembl:ENSDARG00000077308 AllianceGenome:ZFIN:ZDB-GENE-070928-33
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu355; zgc:171802
Summary: Predicted to enable urotensin II receptor activity. Acts upstream of or within response to lipopolysaccharide. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including digestive system; heart; lateral line; macrophage; and ovary. Orthologous to human GPR84 (G protein-coupled receptor 84). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (39114207..39119142)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (39116786..39121606)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of zebrafish gpr84 significantly increased both the phagocytic ability (PA) and phagocytic index (PI) values of the macrophages engulfing the bacteria, suggesting that zebrafish Gpr84 was able to promote the phagocytosis of bacteria by the macrophages.
Title: Zebrafish fatty acids receptor Gpr84 enhances macrophage phagocytosis.
Study reports the identification and characterization of zGpr84 and found that the expression of zGpr84 mRNA was up-regulated after fasting or lipopolysaccharide challenge, indicating the roles of zGpr84 in both nutritional control and immune response.
Title: A medium-chain fatty acid receptor Gpr84 in zebrafish: expression pattern and roles in immune regulation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables urotensin II receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor 84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105697.1 → NP_001099167.1 G-protein coupled receptor 84

See identical proteins and their annotated locations for NP_001099167.1

Status: PROVISIONAL

Source sequence(s)

BC153319

UniProtKB/TrEMBL

A8E4T2

Conserved Domains (2) summary

pfam00001
Location:41 → 226

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:34 → 126

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

39114207..39119142

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476741.1 → XP_021332416.1 G-protein coupled receptor 84 isoform X1

UniProtKB/TrEMBL

A0A8M9QA22

Related

ENSDARP00000118984.1, ENSDART00000136835.2

Conserved Domains (1) summary

cd15210
Location:33 → 387

7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors