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    Rcc1 regulator of chromosome condensation 1 [ Mus musculus (house mouse) ]

    Gene ID: 100088, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rcc1provided by MGI
    Official Full Name
    regulator of chromosome condensation 1provided by MGI
    Primary source
    MGI:MGI:1913989
    See related
    Ensembl:ENSMUSG00000028896 AllianceGenome:MGI:1913989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chc1; 4931417M11Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Predicted to act upstream of or within cell division. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; metanephros; reproductive system; and vibrissa. Orthologous to human RCC1 (regulator of chromosome condensation 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 56.4), CNS E11.5 (RPKM 14.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.3; 4 65.2 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132059230..132073061, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132331919..132345750, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene CRISPRi-validated cis-regulatory element for Rcc1 and Trnau1ap Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene small nucleolar RNA, H/ACA box 73a Neighboring gene small nucleolar RNA host gene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of TFG in mus musculus and Caenorhabditis elegans. Mencinger M, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092511
    2. MYCBP2 Is a Guanosine Exchange Factor for Ran Protein and Determines Its Localization in Neurons of Dorsal Root Ganglia. Dörr A, et al. J Biol Chem, 2015 Oct 16. PMID 26304119, Free PMC Article
    3. Topoisomerase II regulates the maintenance of DNA methylation. Lu LY, et al. J Biol Chem, 2015 Jan 9. PMID 25451918, Free PMC Article
    4. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. Schulze H, et al. J Biol Chem, 2008 May 16. PMID 18347012, Free PMC Article
    5. Ott, a mouse X-linked multigene family expressed specifically during meiosis. Kerr SM, et al. Hum Mol Genet, 1996 Aug. PMID 8842733

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Snhg3

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosomal DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulator of chromosome condensation
    Names
    chromosome condensation protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197082.1 → NP_001184011.1  regulator of chromosome condensation isoform 1

      See identical proteins and their annotated locations for NP_001184011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK076089, AK150610, CJ075381, CR516684
      Consensus CDS
      CCDS57303.1
      UniProtKB/TrEMBL
      Q3U6D2, Q6PFB2
      Related
      ENSMUSP00000030726.7, ENSMUST00000030726.13
      Conserved Domains (2) summary
      pfam00415
      Location:376 → 427
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:187 → 216
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    2. NM_133878.3 → NP_598639.1  regulator of chromosome condensation isoform 2

      See identical proteins and their annotated locations for NP_598639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AK076089, AK150610, CR516684
      Consensus CDS
      CCDS18723.1
      UniProtKB/Swiss-Prot
      Q3UDB6, Q8VE37
      UniProtKB/TrEMBL
      Q3U6D2
      Related
      ENSMUSP00000081271.5, ENSMUST00000084250.11
      Conserved Domains (3) summary
      COG5184
      Location:2 → 419
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:363 → 414
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:174 → 203
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132059230..132073061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE37.1 GenPept UniProtKB/Swiss-Prot:Q8VE37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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