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    BECN1 beclin 1, autophagy related [ Homo sapiens (human) ]

    Gene ID: 8678, updated on 30-Jun-2015
    Official Symbol
    BECN1provided by HGNC
    Official Full Name
    beclin 1, autophagy relatedprovided by HGNC
    Primary source
    HGNC:HGNC:1034
    See related
    Ensembl:ENSG00000126581; HPRD:05087; MIM:604378; Vega:OTTHUMG00000180653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATG6; VPS30; beclin1
    Summary
    Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
    Orthologs
    See BECN1 in Epigenomics, MapViewer
    Location:
    17q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (42810132..42824292, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40962150..40976310, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene cytochrome c oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene microRNA 6781 Neighboring gene proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) Neighboring gene amine oxidase, copper containing 2 (retina-specific)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Asp asp HIV-1 ASP expression upregulates the levels of two autophagy markers, LC3b and Beclin 1 in COS-7 cells, suggesting ASP activates autophagy in mammalian cells PubMed
    Nef nef Genome-wide shRNA screening identifies BECN1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    nef HIV-1 Nef acts as an antiautophagic maturation factor through interaction with the autophagy regulatory factor Beclin 1, leading to protect HIV-1 from degradation PubMed
    capsid gag Knockdown of Beclin 1 (ATG6) results in diminished levels of p24 yields in both primary monocyte- and U937-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    phosphatidylinositol 3-kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    CVT pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activation of mitophagy in response to mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-amyloid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to glucose starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    engulfment of apoptotic cell IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lysosome organization IEA
    Inferred from Electronic Annotation
    more info
     
    macroautophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitochondrion degradation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    receptor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    autophagosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic membrane-bounded vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase complex, class III ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol 3-kinase complex, class III, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylinositol 3-kinase complex, class III, type II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    pre-autophagosomal structure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    beclin-1
    Names
    ATG6 autophagy related 6 homolog
    beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
    beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
    coiled-coil myosin-like BCL2-interacting protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003766.3NP_003757.1  beclin-1

      See identical proteins and their annotated locations for NP_003757.1

      Status: VALIDATED

      Source sequence(s)
      BC010276, BI496049, DC296896
      Consensus CDS
      CCDS11441.1
      UniProtKB/TrEMBL
      A0A024R1X5
      UniProtKB/Swiss-Prot
      Q14457
      Related
      ENSP00000355231, OTTHUMP00000264882, ENST00000361523, OTTHUMT00000452405
      Conserved Domains (3) summary
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam04111
      Location:135450
      APG6; Autophagy protein Apg6
      pfam15285
      Location:105129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      42810132..42824292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257759.2XP_005257816.1  

      Conserved Domains (3) summary
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam04111
      Location:135382
      APG6; Autophagy protein Apg6
      pfam15285
      Location:105129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    2. XM_005257760.2XP_005257817.1  

      See identical proteins and their annotated locations for XP_005257817.1

      UniProtKB/TrEMBL
      W0FFG4
      Conserved Domains (3) summary
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam04111
      Location:135347
      APG6; Autophagy protein Apg6
      pfam15285
      Location:105129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    3. XM_005257758.2XP_005257815.1  

      See identical proteins and their annotated locations for XP_005257815.1

      UniProtKB/TrEMBL
      A0A024R1X5
      UniProtKB/Swiss-Prot
      Q14457
      Related
      ENSP00000465364, OTTHUMP00000264883, ENST00000590099, OTTHUMT00000452407
      Conserved Domains (3) summary
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam04111
      Location:135450
      APG6; Autophagy protein Apg6
      pfam15285
      Location:105129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting
    4. XM_011525421.1XP_011523723.1  

      Conserved Domains (4) summary
      pfam12777
      Location:196269
      MT; Microtubule-binding stalk of dynein motor
      pfam04111
      Location:135350
      APG6; Autophagy protein Apg6
      pfam13900
      Location:347388
      GVQW; Putative binding domain
      pfam15285
      Location:105129
      BH3; Beclin-1 BH3 domain, Bcl-2-interacting

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      41197767..41211922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)