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    MS4A14 membrane-spanning 4-domains, subfamily A, member 14 [ Homo sapiens (human) ]

    Gene ID: 84689, updated on 26-Jun-2015
    Official Symbol
    MS4A14provided by HGNC
    Official Full Name
    membrane-spanning 4-domains, subfamily A, member 14provided by HGNC
    Primary source
    HGNC:HGNC:30706
    See related
    Ensembl:ENSG00000166928; HPRD:14863; Vega:OTTHUMG00000167357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MS4A16; NYD-SP21
    Orthologs
    See MS4A14 in Epigenomics, MapViewer
    Location:
    11q12.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (60396014..60417756)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60163487..60185229)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane-spanning 4-domains, subfamily A, member 6E Neighboring gene membrane-spanning 4-domains, subfamily A, member 7 Neighboring gene membrane-spanning 4-domains, subfamily A, member 5 Neighboring gene membrane-spanning 4-domains, subfamily A, member 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Potential readthrough

    Included gene: MS4A7

    Clone Names

    • MGC49828, MGC104289

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    membrane-spanning 4-domains subfamily A member 14
    Names
    membrane-spanning 4-domains subfamily A member 14
    MS4A13 protein
    membrane-spanning 4-domains, subfamily A, member 16
    testes development-related NYD-SP21
    testis development protein NYD-SP21

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079692.2NP_001073160.1  membrane-spanning 4-domains subfamily A member 14 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 4, which results in a shorter protein (isoform 2), compared to isoform 4.
      Source sequence(s)
      AP003127, AY094611
      Consensus CDS
      CCDS41652.1
      UniProtKB/Swiss-Prot
      Q96JA4
      Related
      ENSP00000378453, OTTHUMP00000236362, ENST00000395005, OTTHUMT00000395384
      Conserved Domains (1) summary
      pfam04103
      Location:44142
      CD20; CD20-like family
    2. NM_001261827.1NP_001248756.1  membrane-spanning 4-domains subfamily A member 14 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 4, which results in a shorter protein (isoform 3), compared to isoform 4.
      Source sequence(s)
      AK057418, AP003127, DB082055
      Consensus CDS
      CCDS73295.1
      UniProtKB/TrEMBL
      A0A0A0MS57
      Related
      ENSP00000378449, ENST00000395001
      Conserved Domains (1) summary
      pfam04103
      Location:44123
      CD20; CD20-like family
    3. NM_001261828.1NP_001248757.1  membrane-spanning 4-domains subfamily A member 14 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AP003127, BC064627, DB727789
      Consensus CDS
      CCDS58136.1
      UniProtKB/Swiss-Prot
      Q96JA4
      Related
      ENSP00000433761, OTTHUMP00000236367, ENST00000531783, OTTHUMT00000395389
      Conserved Domains (1) summary
      pfam04103
      Location:44140
      CD20; CD20-like family
    4. NM_032597.4NP_115986.3  membrane-spanning 4-domains subfamily A member 14 isoform 1

      See identical proteins and their annotated locations for NP_115986.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has multiple coding region differences, compared to variant 4, which results in a shorter protein (isoform 1), compared to isoform 4.
      Source sequence(s)
      AP003127, AY094610
      Consensus CDS
      CCDS31569.1
      UniProtKB/Swiss-Prot
      Q96JA4
      Related
      ENSP00000300187, OTTHUMP00000236361, ENST00000300187, OTTHUMT00000395383
      Conserved Domains (1) summary
      pfam04103
      Location:44159
      CD20; CD20-like family

    RNA

    1. NR_049731.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK057418, AP003127
    2. NR_049732.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP003127, BC064627
    3. NR_049733.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK057418, AP003127, BC035361
    4. NR_049734.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) includes an alternate exon in the coding region, compared to variant 4, which results in the introduction of an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein product is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP003127, DB450359

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      60396014..60417756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      60029518..60051230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)