Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    MMZ3 MMS ZWEI-like protein 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818179, updated on 7-Jun-2015
    Gene symbol
    MMZ3
    Gene description
    MMS ZWEI-like protein 3
    Primary source
    TAIR:AT2G36060
    Locus tag
    AT2G36060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F11F19.3; F11F19_3; MMS ZWEI homologue 3; MMZ3; UBIQUITIN E2 VARIANT 1C; UEV1C
    Summary
    MMZ3/UEV1C encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1C can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. It can also rescue an mms2 ubc13 double mutant in yeast in combination with UBC13A. MMZ3/UEV1C transcripts are found at moderate levels in most plant organs, but cannot be detected in the pollen or 2 days after germination. Transcript levels do not appear to be stress-inducible.
    See MMZ3 in MapViewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (15142677..15144182, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ovate family protein 15 Neighboring gene hypothetical protein Neighboring gene translocase inner membrane subunit 44-2 Neighboring gene protein ABNORMAL SHOOT 2

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    • Homologs of the MMZ3 gene: The MMZ3 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
    NM_001084542.1
    NM_129165.3
    NM_179928.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    RNA processing RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    mitotic cell cycle RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    postreplication repair RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-dependent protein catabolic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    UBC13-MMS2 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISM
    Inferred from Sequence Model
    more info
     
    Names
    MMS ZWEI-like protein 3
    NP_001078011.1
    • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.1); Has 2913 Blast hits to 2913 proteins in 284 species: Archae - 0; Bacteria - 0; Metazoa - 1555; Fungi - 342; Plants - 599; Viruses - 0; Other Eukaryotes - 417 (source: NCBI BLink).
    NP_565834.1
    • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.1); Has 2912 Blast hits to 2912 proteins in 287 species: Archae - 0; Bacteria - 0; Metazoa - 1566; Fungi - 354; Plants - 579; Viruses - 0; Other Eukaryotes - 413 (source: NCBI BLink).
    NP_850259.1
    • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.2); Has 1347 Blast hits to 1347 proteins in 246 species: Archae - 0; Bacteria - 0; Metazoa - 655; Fungi - 163; Plants - 359; Viruses - 0; Other Eukaryotes - 170 (source: NCBI BLink).

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15142677..15144182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001084542.1NP_001078011.1  MMS ZWEI-like protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078011.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SJ44
      Conserved Domains (1) summary
      smart00212
      Location:16141
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    2. NM_129165.3NP_565834.1  MMS ZWEI-like protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565834.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SJ44
      Conserved Domains (1) summary
      smart00212
      Location:16142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    3. NM_179928.2NP_850259.1  MMS ZWEI-like protein 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SJ44
      Conserved Domains (1) summary
      smart00212
      Location:16143
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues