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    NDEL1 nudE neurodevelopment protein 1-like 1 [ Homo sapiens (human) ]

    Gene ID: 81565, updated on 27-Jun-2015
    Official Symbol
    NDEL1provided by HGNC
    Official Full Name
    nudE neurodevelopment protein 1-like 1provided by HGNC
    Primary source
    HGNC:HGNC:17620
    See related
    Ensembl:ENSG00000166579; HPRD:06340; MIM:607538; Vega:OTTHUMG00000108193
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EOPA; NDE2; NUDEL; MITAP1; NDE1L1
    Summary
    This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]
    Orthologs
    See NDEL1 in Epigenomics, MapViewer
    Location:
    17p13.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (8435852..8471708)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8316447..8371495)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371523 Neighboring gene ribosomal protein L26 Neighboring gene ring finger protein 222 Neighboring gene uncharacterized LOC105371524 Neighboring gene myosin, heavy chain 10, non-muscle Neighboring gene uncharacterized LOC102724262 Neighboring gene RNA, U7 small nuclear 43 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
      Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
      Lissencephaly gene (LIS1) in neuronal migration and development
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
    • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
      Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate Formins, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate Formins, organism-specific biosystemFormins are a family of proteins with 15 members in mammals, organized into 8 subfamilies. Formins are involved in the regulation of actin cytoskeleton. Many but not all formin family members are act...
    • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
      Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
    • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
      Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp451M0318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oligopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    central nervous system neuron axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of chromosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inner cell mass cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    mitotic centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neurofilament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection extension IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    retrograde axon cargo transport IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    axon hillock IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    neurofilament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    spindle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    nuclear distribution protein nudE-like 1
    Names
    nuclear distribution protein nudE-like 1
    endooligopeptidase A
    mitosin-associated protein 1
    mitosin-associated protein MITAP1
    nudE nuclear distribution E homolog-like 1
    nudE nuclear distribution gene E homolog-like 1
    protein Nudel

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029963.2 RefSeqGene

      Range
      4992..37317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025579.2NP_001020750.1  nuclear distribution protein nudE-like 1 isoform A

      See identical proteins and their annotated locations for NP_001020750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (A).
      Source sequence(s)
      AA425741, AF217798, AI742227, CX166766, DA256375, DB176966
      Consensus CDS
      CCDS32564.1
      UniProtKB/Swiss-Prot
      Q9GZM8
      Conserved Domains (2) summary
      pfam04880
      Location:135315
      NUDE_C; NUDE protein, C-terminal conserved region
      cl03075
      Location:64150
      GrpE; nucleotide exchange factor GrpE
    2. NM_030808.4NP_110435.1  nuclear distribution protein nudE-like 1 isoform B

      See identical proteins and their annotated locations for NP_110435.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1. The encoded isoform (B) is longer and has a distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AA425741, AF182078, AI742227, DB176966
      Consensus CDS
      CCDS11143.1
      UniProtKB/Swiss-Prot
      Q9GZM8
      Related
      ENSP00000333982, OTTHUMP00000135335, ENST00000334527, OTTHUMT00000226999
      Conserved Domains (2) summary
      pfam09727
      Location:35139
      CortBP2; Cortactin-binding protein-2
      pfam04880
      Location:135336
      NUDE_C; NUDE protein, C-terminal conserved region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      8435852..8471708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524012.1XP_011522314.1  

      Conserved Domains (2) summary
      pfam04880
      Location:135321
      NUDE_C; NUDE protein, C-terminal conserved region
      cl03075
      Location:28127
      GrpE; nucleotide exchange factor GrpE
    2. XM_011524013.1XP_011522315.1  

      Related
      ENSP00000369364, OTTHUMP00000259663, ENST00000380025, OTTHUMT00000442478
      Conserved Domains (2) summary
      pfam04880
      Location:135252
      NUDE_C; NUDE protein, C-terminal conserved region
      cl03075
      Location:64150
      GrpE; nucleotide exchange factor GrpE
    3. XM_006721580.2XP_006721643.1  

      Conserved Domains (2) summary
      pfam04880
      Location:135324
      NUDE_C; NUDE protein, C-terminal conserved region
      cl03075
      Location:64150
      GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      8348024..8380341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)