Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase [ Mus musculus (house mouse) ]

    Gene ID: 75678, updated on 27-Jun-2015
    Official Symbol
    Ippkprovided by MGI
    Official Full Name
    inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by MGI
    Primary source
    MGI:MGI:1922928
    See related
    Ensembl:ENSMUSG00000021385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    InsP6; 1810043M15Rik
    Orthologs
    See Ippk in Epigenomics, MapViewer
    Location:
    13; 13 A5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (49421223..49463060)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (49516680..49558359)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene bicaudal D homolog 2 (Drosophila) Neighboring gene predicted gene, 29842 Neighboring gene centromere protein P Neighboring gene testis derived transcript 3, pseudogene Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    inositol pentakisphosphate 2-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of mitophagy in response to mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    inositol phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    inositol-pentakisphosphate 2-kinase
    Names
    inositol-pentakisphosphate 2-kinase
    ins(1,3,4,5,6)P5 2-kinase
    insP5 2-kinase
    NP_001263328.1
    NP_951011.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276399.1NP_001263328.1  inositol-pentakisphosphate 2-kinase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK007761, AK031987, AV306360, CD353694
      Conserved Domains (1) summary
      pfam06090
      Location:76505
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
    2. NM_199056.3NP_951011.1  inositol-pentakisphosphate 2-kinase isoform a

      See identical proteins and their annotated locations for NP_951011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AC123954, AK167467, AV306360
      Consensus CDS
      CCDS26500.1
      UniProtKB/Swiss-Prot
      Q6P1C1
      Related
      ENSMUSP00000021817, ENSMUST00000021817
      Conserved Domains (1) summary
      pfam06090
      Location:13456
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    RNA

    1. NR_075085.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123954, AK160092, AV306360, BB619387, CD353694, DV647168

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

      Range
      49421223..49463060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000035.1 Alternate Mm_Celera

      Range
      50510738..50552680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)