WNT7B Wnt family member 7B [Homo sapiens (human)] - Gene

Summary

Official Symbol: WNT7Bprovided by HGNC
Official Full Name: Wnt family member 7Bprovided by HGNC
Primary source: HGNC:HGNC:12787
See related: Ensembl:ENSG00000188064 MIM:601967; AllianceGenome:HGNC:12787
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
Expression: Biased expression in skin (RPKM 7.3), urinary bladder (RPKM 3.8) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (45920366..45977162, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (46405017..46461763, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (46316246..46373042, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans.
Title: Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans.
EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.
Title: EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.
Inhibition of Wnt7b reduces the proliferation, invasion, and migration of colorectal cancer cells.
Title: Inhibition of Wnt7b reduces the proliferation, invasion, and migration of colorectal cancer cells.
A WNT7B-m(6)A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis.
Title: A WNT7B-m(6)A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis.
Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren's Contracture.
Title: Evaluation of WNT Signaling Pathway Gene Variants WNT7B rs6519955, SFRP4 rs17171229 and RSPO2 rs611744 in Patients with Dupuytren's Contracture.
The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity.
Title: The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity.
Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells.
Title: Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells.
WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.
Title: WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.
TCP1 regulates Wnt7b/beta-catenin pathway through P53 to influence the proliferation and migration of hepatocellular carcinoma cells.
Title: TCP1 regulates Wnt7b/β-catenin pathway through P53 to influence the proliferation and migration of hepatocellular carcinoma cells.
Extracellular vesicular Wnt7b mediates HPV E6-induced cervical cancer angiogenesis by activating the beta-catenin signaling pathway.
Title: Extracellular vesicular Wnt7b mediates HPV E6-induced cervical cancer angiogenesis by activating the β-catenin signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Wnt signaling and Dupuytren's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt7b (e-PCR), detects polymorphism
- UniSTS:465426

Wnt7b (e-PCR), detects polymorphism
- UniSTS:471330

AL022549 (e-PCR)
- UniSTS:66378

D22S1130 (e-PCR)
- UniSTS:154206

D10S16 (e-PCR)
- UniSTS:155756

DXS7011E (e-PCR)
- UniSTS:98946

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway, planar cell polarity pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemoattraction of dopaminergic neuron axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in chorio-allantoic fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in developmental growth involved in morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic organ development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic placenta morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of polarity of embryonic epithelium	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in forebrain regionalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in homeostatic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in in utero embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner medullary collecting duct development	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular oxygen homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lens fiber cell development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in lobar bronchus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland epithelium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in metanephric collecting duct development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric loop of Henle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephros morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in outer medullary collecting duct development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell projection size	IEA Inferred from Electronic Annotation more info
involved_in renal inner medulla development	ISS Inferred from Sequence or Structural Similarity more info
involved_in renal outer medulla development	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in trachea cartilage morphogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: protein Wnt-7b

Names: wingless-type MMTV integration site family, member 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.