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    Marveld3 MARVEL (membrane-associating) domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 73608, updated on 26-Jun-2015
    Official Symbol
    Marveld3provided by MGI
    Official Full Name
    MARVEL (membrane-associating) domain containing 3provided by MGI
    Primary source
    MGI:MGI:1920858
    See related
    Ensembl:ENSMUSG00000001672; Vega:OTTMUSG00000027477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Marvd3; Mrvldc3; AI642133; 1810006A16Rik
    Orthologs
    See Marveld3 in Epigenomics, MapViewer
    Location:
    8; 8 D3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (109947909..109962205, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (112471809..112486105, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene adaptor protein complex AP-1, gamma 1 subunit Neighboring gene uncharacterized LOC102638694 Neighboring gene PH domain and leucine rich repeat protein phosphatase 2 Neighboring gene RIKEN cDNA 1700064F23 gene Neighboring gene tyrosine aminotransferase

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    MARVEL domain-containing protein 3
    Names
    MARVEL domain-containing protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028584.3NP_082860.2  MARVEL domain-containing protein 3 isoform a

      See identical proteins and their annotated locations for NP_082860.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AK007346, AV360109, AW107118, BB619320, BY088355
      Consensus CDS
      CCDS22657.1
      UniProtKB/TrEMBL
      G3X9A4
      UniProtKB/Swiss-Prot
      Q9D956
      Related
      ENSMUSP00000052309, OTTMUSP00000034300, ENSMUST00000051430, OTTMUST00000068003
      Conserved Domains (2) summary
      PHA03231
      Location:341374
      PHA03231; glycoprotein BALF4; Provisional
      pfam01284
      Location:230355
      MARVEL; Membrane-associating domain
    2. NM_212447.2NP_997612.2  MARVEL domain-containing protein 3 isoform b

      See identical proteins and their annotated locations for NP_997612.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AC122807, AK007346, BB619320, BY088355
      Consensus CDS
      CCDS22656.1
      UniProtKB/TrEMBL
      G3X8Q2
      UniProtKB/Swiss-Prot
      Q9D956
      Related
      ENSMUSP00000001722, OTTMUSP00000034301, ENSMUST00000001722, OTTMUST00000068004
      Conserved Domains (1) summary
      pfam01284
      Location:168352
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

      Range
      109947909..109962205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000030.1 Alternate Mm_Celera

      Range
      114169861..114184142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)