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    Usp13 ubiquitin specific peptidase 13 (isopeptidase T-3) [ Mus musculus (house mouse) ]

    Gene ID: 72607, updated on 26-Jun-2015
    Official Symbol
    Usp13provided by MGI
    Official Full Name
    ubiquitin specific peptidase 13 (isopeptidase T-3)provided by MGI
    Primary source
    MGI:MGI:1919857
    See related
    Ensembl:ENSMUSG00000056900; Vega:OTTMUSG00000023838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ISOT3; IsoT-3; AI848077; 2700071E21Rik
    Orthologs
    See Usp13 in Epigenomics, MapViewer
    Location:
    3; 3 A3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (32817019..32938075)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (32716548..32834179)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 Neighboring gene peroxisomal biogenesis factor 5-like Neighboring gene predicted gene, 34153 Neighboring gene RIKEN cDNA 4930419G24 gene

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Markers

    Homology

    Clone Names

    • MGC107670

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    omega peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    proteasome binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ER-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteasomal protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with BAT3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 13
    Names
    ubiquitin carboxyl-terminal hydrolase 13
    deubiquitinating enzyme 13
    ubiquitin specific protease 13 (isopeptidase T-3)
    ubiquitin thioesterase 13
    ubiquitin-specific-processing protease 13
    NP_001013042.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013024.2NP_001013042.1  ubiquitin carboxyl-terminal hydrolase 13

      See identical proteins and their annotated locations for NP_001013042.1

      Status: PROVISIONAL

      Source sequence(s)
      AC111140
      Consensus CDS
      CCDS17301.1
      UniProtKB/Swiss-Prot
      Q5BKP2
      Conserved Domains (4) summary
      COG5207
      Location:28856
      UBP14; Isopeptidase T [Posttranslational modification, protein turnover, chaperones]
      cd00194
      Location:725761
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd02658
      Location:335854
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:209282
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

      Range
      32817019..32938075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535554.2XP_006535617.1  

      Conserved Domains (2) summary
      cd02658
      Location:335612
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:209282
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. XM_006535553.2XP_006535616.1  

      Related
      ENSMUSP00000072155, OTTMUSP00000028179, ENSMUST00000072312, OTTMUST00000058225
      Conserved Domains (4) summary
      COG5207
      Location:28768
      UBP14; Isopeptidase T [Posttranslational modification, protein turnover, chaperones]
      cd00194
      Location:637673
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      cd02658
      Location:335766
      Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam02148
      Location:209282
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    3. XM_006535555.2XP_006535618.1  

      Conserved Domains (3) summary
      COG5207
      Location:28490
      UBP14; Isopeptidase T [Posttranslational modification, protein turnover, chaperones]
      pfam02148
      Location:209282
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl02553
      Location:335568
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    Alternate Mm_Celera

    Genomic

    1. AC_000025.1 Alternate Mm_Celera

      Range
      32725174..32842630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)