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    Fis1 fission 1 (mitochondrial outer membrane) homolog (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 66437, updated on 27-Jun-2015
    Official Symbol
    Fis1provided by MGI
    Official Full Name
    fission 1 (mitochondrial outer membrane) homolog (yeast)provided by MGI
    Primary source
    MGI:MGI:1913687
    See related
    Ensembl:ENSMUSG00000019054; Vega:OTTMUSG00000023394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttc11; 2010003O14Rik
    Orthologs
    See Fis1 in Epigenomics, MapViewer
    Location:
    5; 5 G1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (136953264..136966234)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137429145..137442104)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 22 Neighboring gene RIKEN cDNA 4933404O12 gene Neighboring gene claudin 15 Neighboring gene zinc finger, HIT domain containing 1 Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling using intracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion degradation ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    mitochondrial fission 1 protein
    Names
    mitochondrial fission 1 protein
    FIS1 homolog
    TPR repeat protein 11
    tetratricopeptide repeat domain 11
    tetratricopeptide repeat protein 11

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163243.1NP_001156715.1  mitochondrial fission 1 protein isoform 2

      See identical proteins and their annotated locations for NP_001156715.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK008078, CA322565, CD774298
      Consensus CDS
      CCDS51669.1
      UniProtKB/TrEMBL
      G3X9U9
      UniProtKB/Swiss-Prot
      Q9CQ92
      Related
      ENSMUSP00000106723, OTTMUSP00000027341, ENSMUST00000111094, OTTMUST00000056795
      Conserved Domains (1) summary
      cd12212
      Location:8116
      Fis1; Mitochondria Fission Protein Fis1, cytosolic domain
    2. NM_025562.3NP_079838.1  mitochondrial fission 1 protein isoform 1

      See identical proteins and their annotated locations for NP_079838.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK008078, AW988976, CD774298
      Consensus CDS
      CCDS19757.1
      UniProtKB/Swiss-Prot
      Q9CQ92
      Related
      ENSMUSP00000019198, OTTMUSP00000027340, ENSMUST00000019198, OTTMUST00000056794
      Conserved Domains (1) summary
      cd12212
      Location:9123
      Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      136953264..136966234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504489.1XP_006504552.1  

      UniProtKB/TrEMBL
      D3YZ32
      Conserved Domains (1) summary
      cd12212
      Location:1473
      Fis1; Mitochondria Fission Protein Fis1, cytosolic domain

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      133969492..133982284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)