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    ACTR3B ARP3 actin-related protein 3 homolog B (yeast) [ Homo sapiens (human) ]

    Gene ID: 57180, updated on 26-Jun-2015
    Official Symbol
    ACTR3Bprovided by HGNC
    Official Full Name
    ARP3 actin-related protein 3 homolog B (yeast)provided by HGNC
    Primary source
    HGNC:HGNC:17256
    See related
    Ensembl:ENSG00000133627; HPRD:12489; Vega:OTTHUMG00000151463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARP11; ARP3BETA
    Summary
    This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
    Orthologs
    See ACTR3B in Epigenomics, MapViewer
    Location:
    7q36.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (152759749..152887759)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (152456834..152552464)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 2 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 pseudogene 3 Neighboring gene uncharacterized LOC105375575 Neighboring gene small ubiquitin-related modifier 2-like

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686O24114

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    actin-related protein 3B
    Names
    actin-related protein 3B
    ARP3-beta
    actin-like protein 3B
    actin-related protein 3-beta
    actin-related protein ARP4
    actin-related protein Arp11

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040135.2NP_001035225.1  actin-related protein 3B isoform 2

      See identical proteins and their annotated locations for NP_001035225.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AA559050, AB209174, AK294292, BC015207, DN601600
      Consensus CDS
      CCDS34782.1
      UniProtKB/TrEMBL
      Q59GD5
      UniProtKB/Swiss-Prot
      Q9P1U1
      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2347
      PTZ00280; Actin-related protein 3; Provisional
    2. NM_020445.5NP_065178.1  actin-related protein 3B isoform 1

      See identical proteins and their annotated locations for NP_065178.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA559050, AB209174, AK315534, DN601600
      Consensus CDS
      CCDS5934.1
      UniProtKB/TrEMBL
      Q59GD5
      UniProtKB/Swiss-Prot
      Q9P1U1
      Related
      ENSP00000256001, OTTHUMP00000200076, ENST00000256001, OTTHUMT00000322803
      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2417
      PTZ00280; Actin-related protein 3; Provisional

    RNA

    1. NR_073000.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA559050, AB209174, AK294292, DN601600
    2. NR_073001.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA559050, AB209174, AK315534, AK316078, DN601600

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

      Range
      152759749..152887759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716065.2XP_006716128.1  

      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2317
      PTZ00280; Actin-related protein 3; Provisional
    2. XM_011516425.1XP_011514727.1  

      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2317
      PTZ00280; Actin-related protein 3; Provisional
    3. XM_011516426.1XP_011514728.1  

      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2321
      PTZ00280; Actin-related protein 3; Provisional
    4. XM_006716067.2XP_006716130.1  

      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2319
      PTZ00280; Actin-related protein 3; Provisional
    5. XM_011516427.1XP_011514729.1  

      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2317
      PTZ00280; Actin-related protein 3; Provisional
    6. XM_006716066.1XP_006716129.1  

      Conserved Domains (2) summary
      cd00012
      Location:9196
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:2320
      PTZ00280; Actin-related protein 3; Provisional
    7. XM_006716068.2XP_006716131.1  

      See identical proteins and their annotated locations for XP_006716131.1

      Conserved Domains (2) summary
      cd00012
      Location:2567
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:1288
      PTZ00280; Actin-related protein 3; Provisional
    8. XM_011516428.1XP_011514730.1  

      See identical proteins and their annotated locations for XP_011514730.1

      Conserved Domains (2) summary
      cd00012
      Location:2567
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      PTZ00280
      Location:1288
      PTZ00280; Actin-related protein 3; Provisional

    RNA

    1. XR_927492.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      152465204..152560884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)