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    Gsk3b glycogen synthase kinase 3 beta [ Mus musculus (house mouse) ]

    Gene ID: 56637, updated on 27-Jun-2015
    Official Symbol
    Gsk3bprovided by MGI
    Official Full Name
    glycogen synthase kinase 3 betaprovided by MGI
    Primary source
    MGI:MGI:1861437
    See related
    Ensembl:ENSMUSG00000022812; Vega:OTTMUSG00000016276
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GSK3; GSK-3; C86142; GSK-3beta; 7330414F15Rik; 8430431H08Rik
    Orthologs
    See Gsk3b in Epigenomics, MapViewer
    Location:
    16; 16 B4
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (38089001..38246080)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (38089087..38246165)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 156 Neighboring gene predicted gene, 36225 Neighboring gene RIKEN cDNA 4930542C21 gene Neighboring gene cDNA sequence BC031361 Neighboring gene nuclear receptor subfamily 1, group I, member 2 Neighboring gene MYCBP-associated, testis expressed 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    tau-protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tau-protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ER overload response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER overload response ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway involved in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to interleukin-3 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    hippocampus development ISO
    Inferred from Sequence Orthology
    more info
     
    hypermethylation of CpG island IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    myoblast fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    myotube differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NFAT protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron maturation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to microtubule IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    re-entry into mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression by genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microtubule-based process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    superior temporal gyrus development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glycogen synthase kinase-3 beta
    Names
    glycogen synthase kinase-3 beta
    GSK-3 beta
    serine/threonine-protein kinase GSK3B
    NP_062801.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019827.6NP_062801.1  glycogen synthase kinase-3 beta

      See identical proteins and their annotated locations for NP_062801.1

      Status: PROVISIONAL

      Source sequence(s)
      AC120020, AC154284
      Consensus CDS
      CCDS28163.1
      UniProtKB/TrEMBL
      Q5KU03
      UniProtKB/Swiss-Prot
      Q9WV60
      Related
      ENSMUSP00000023507, OTTMUSP00000017445, ENSMUST00000023507, OTTMUST00000039047
      Conserved Domains (2) summary
      pfam00069
      Location:56340
      Pkinase; Protein kinase domain
      cd14137
      Location:51343
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

      Range
      38089001..38246080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522425.1XP_006522488.1  

      UniProtKB/TrEMBL
      E9QAQ5
      Conserved Domains (2) summary
      pfam00069
      Location:56353
      Pkinase; Protein kinase domain
      cd14137
      Location:51356
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    2. XM_006522426.2XP_006522489.1  

      Conserved Domains (1) summary
      cd14137
      Location:1256
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      38497488..38655086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)