Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    WAC WW domain containing adaptor with coiled-coil [ Homo sapiens (human) ]

    Gene ID: 51322, updated on 27-Jun-2015
    Official Symbol
    WACprovided by HGNC
    Official Full Name
    WW domain containing adaptor with coiled-coilprovided by HGNC
    Primary source
    HGNC:HGNC:17327
    See related
    Ensembl:ENSG00000095787; HPRD:18291; MIM:615049; Vega:OTTHUMG00000017872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Wwp4; BM-016; PRO1741
    Summary
    The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Orthologs
    Location:
    10p12.1; 10p12.1-p11.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (28532588..28623112)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (28821355..28912041)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376469 Neighboring gene WAC antisense RNA 1 (head to head) Neighboring gene TP53RK binding protein pseudogene 1 Neighboring gene BMP and activin membrane-bound inhibitor

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC10753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II core binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    WW domain-containing adapter protein with coiled-coil
    Names
    WW domain-containing adapter protein with coiled-coil

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016628.4NP_057712.2  WW domain-containing adapter protein with coiled-coil isoform 1

      See identical proteins and their annotated locations for NP_057712.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK290174, AL161936, CB143386
      Consensus CDS
      CCDS7159.1
      UniProtKB/Swiss-Prot
      Q9BTA9
      Conserved Domains (1) summary
      cd00201
      Location:133162
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    2. NM_100264.2NP_567822.1  WW domain-containing adapter protein with coiled-coil isoform 2

      See identical proteins and their annotated locations for NP_567822.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, comapared to isoform 1.
      Source sequence(s)
      AA424883, AK225846, AL161936, BI463901
      Consensus CDS
      CCDS7161.1
      UniProtKB/Swiss-Prot
      Q9BTA9
      Related
      ENSP00000364816, OTTHUMP00000019382, ENST00000375664, OTTHUMT00000047370
      Conserved Domains (1) summary
      cd00201
      Location:88117
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    3. NM_100486.3NP_567823.1  WW domain-containing adapter protein with coiled-coil isoform 3

      See identical proteins and their annotated locations for NP_567823.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a coding exon but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL161936, BC010356, BI226998, CB143386
      Consensus CDS
      CCDS7160.1
      UniProtKB/Swiss-Prot
      Q9BTA9
      Conserved Domains (1) summary
      cd00201
      Location:133162
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      28532588..28623112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519491.1XP_011517793.1  

      See identical proteins and their annotated locations for XP_011517793.1

      Conserved Domains (1) summary
      cd00201
      Location:88117
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    2. XM_005252454.2XP_005252511.1  

      Related
      ENSP00000346986, OTTHUMP00000019383, ENST00000354911, OTTHUMT00000047371
      Conserved Domains (1) summary
      cd00201
      Location:139168
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    RNA

    1. XR_930491.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      28822063..28912537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)