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    ODF1 outer dense fiber of sperm tails 1 [ Homo sapiens (human) ]

    Gene ID: 4956, updated on 26-Jun-2015
    Official Symbol
    ODF1provided by HGNC
    Official Full Name
    outer dense fiber of sperm tails 1provided by HGNC
    Primary source
    HGNC:HGNC:8113
    See related
    Ensembl:ENSG00000155087; HPRD:01687; MIM:182878; Vega:OTTHUMG00000164719
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ODF; RT7; ODF2; ODFP; SODF; CT133; ODF27; ODFPG; HSPB10; ODFPGA; ODFPGB
    Summary
    The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]
    Orthologs
    See ODF1 in Epigenomics, MapViewer
    Location:
    8q22.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (102551620..102561017)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (103563848..103573245)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S12 pseudogene 15 Neighboring gene uncharacterized LOC105375684 Neighboring gene POU class 5 homeobox 1 pseudogene 2 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene Kruppel-like factor 10

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC129928, MGC129929

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    outer dense fiber IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    outer dense fiber protein 1
    Names
    outer dense fiber protein 1
    cancer/testis antigen 133
    outer dense fiber of sperm tails, 27-kD

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028006.1 RefSeqGene

      Range
      5001..14398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024410.3NP_077721.2  outer dense fiber protein 1

      See identical proteins and their annotated locations for NP_077721.2

      Status: REVIEWED

      Source sequence(s)
      AP002851, BG214987, DB457574
      Consensus CDS
      CCDS6293.1
      UniProtKB/Swiss-Prot
      Q14990
      Related
      ENSP00000285402, OTTHUMP00000227289, ENST00000285402, OTTHUMT00000379884
      Conserved Domains (1) summary
      cd06482
      Location:116202
      ACD_HspB10; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

      Range
      102551620..102561017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      103604099..103613495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)