Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    ABLIM1 actin binding LIM protein 1 [ Homo sapiens (human) ]

    Gene ID: 3983, updated on 30-Jun-2015
    Official Symbol
    ABLIM1provided by HGNC
    Official Full Name
    actin binding LIM protein 1provided by HGNC
    Primary source
    HGNC:HGNC:78
    See related
    Ensembl:ENSG00000099204; HPRD:03819; MIM:602330; Vega:OTTHUMG00000019088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABLIM; LIMAB1; LIMATIN; abLIM-1
    Summary
    This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    See ABLIM1 in Epigenomics, MapViewer
    Location:
    10q25
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (114431110..114821643, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116190869..116444762, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene aurora kinase A pseudogene 2 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene uncharacterized LOC105378494 Neighboring gene actin filament associated protein 1-like 2 Neighboring gene uncharacterized LOC105378495 Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene 19 Neighboring gene uncharacterized LOC101927692 Neighboring gene TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa pseudogene 2 Neighboring gene family with sequence similarity 160, member B1 Neighboring gene ribosomal protein L15 pseudogene 13 Neighboring gene TruB pseudouridine (psi) synthase family member 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • DCC mediated attractive signaling, organism-specific biosystem (from REACTOME)
      DCC mediated attractive signaling, organism-specific biosystemThe DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosi...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC1224, FLJ14564, KIAA0059, DKFZp781D0148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    visual perception TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    actin-binding LIM protein 1
    Names
    actin-binding LIM protein family member 1
    actin-binding double-zinc-finger protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029872.1 RefSeqGene

      Range
      5001..258546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003407.1NP_001003407.1  actin-binding LIM protein 1 isoform b

      See identical proteins and their annotated locations for NP_001003407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (b) contains a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AA314019, AF005654, AI680726, AK058007, AK093471, AK122891, AL600892, AW627433, BC002448, BE395092, BE672277, BG426037, BQ721521, CA450184, CB128609, CD558045, D31883
      Consensus CDS
      CCDS31288.1
      UniProtKB/TrEMBL
      B3KSG3
      UniProtKB/Swiss-Prot
      O14639
      Related
      ENSP00000376682, OTTHUMP00000020531, ENST00000392955, OTTHUMT00000050470
      Conserved Domains (6) summary
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:683718
      VHP; Villin headpiece domain
      cl14106
      Location:520580
      Rifin_STEVOR; Rifin/stevor family
    2. NM_001003408.1NP_001003408.1  actin-binding LIM protein 1 isoform c

      See identical proteins and their annotated locations for NP_001003408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. The resulting isoform (c) contains a distinct N-terminus and is shorter, compared to isoform a.
      Source sequence(s)
      AA314019, AF005654, AI680726, AK058007, AK093471, AK122891, AL600892, AW627433, BC002448, BE395092, BE672277, BG426037, BQ721521, CA450184, CB128609, CD558045, D31883
      UniProtKB/TrEMBL
      B3KSG3
      UniProtKB/Swiss-Prot
      O14639
      Related
      ENSP00000358256, ENST00000369252
      Conserved Domains (6) summary
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:711746
      VHP; Villin headpiece domain
      cl14106
      Location:548608
      Rifin_STEVOR; Rifin/stevor family
    3. NM_002313.5NP_002304.3  actin-binding LIM protein 1 isoform a

      See identical proteins and their annotated locations for NP_002304.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as ABLIM-l, encodes the longest isoform (a).
      Source sequence(s)
      AA314019, AF005654, AI680726, AK058007, AK093471, AK122891, AL600892, AL712271, AW627433, BC002448, BE395092, BE672277, BG426037, BQ721521, CA450184, CB128609, CD558045, D31883
      Consensus CDS
      CCDS7590.1
      UniProtKB/TrEMBL
      B3KSG3
      UniProtKB/Swiss-Prot
      O14639
      Conserved Domains (6) summary
      cd09327
      Location:99150
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:155210
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:226277
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:285340
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:743778
      VHP; Villin headpiece domain
      cl14106
      Location:580640
      Rifin_STEVOR; Rifin/stevor family
    4. NM_006720.3NP_006711.3  actin-binding LIM protein 1 isoform s

      See identical proteins and their annotated locations for NP_006711.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as ABLIM-s, contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. It also uses a downstream start codon, compared to variant 1. The resulting isoform (s) is shorter, compared to isoform a.
      Source sequence(s)
      AI680726, AK058007, AK093471, AK122891, AL600892, AL710059, AW627433, BC002448, BE395092, BE672277, BG426037, BQ721521, CA450184, CB128609, CD558045, D31883
      Consensus CDS
      CCDS31289.1
      UniProtKB/TrEMBL
      B3KSG3
      UniProtKB/Swiss-Prot
      O14639
      Related
      ENSP00000376679, OTTHUMP00000020536, ENST00000392952, OTTHUMT00000050477
      Conserved Domains (3) summary
      pfam02209
      Location:420455
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:257317
      Rifin_STEVOR; Rifin/stevor family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      114431110..114821643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539805.1XP_011538107.1  

      Conserved Domains (5) summary
      cd09328
      Location:358
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:661696
      VHP; Villin headpiece domain
      cl14106
      Location:498558
      Rifin_STEVOR; Rifin/stevor family
    2. XM_011539803.1XP_011538105.1  

      Conserved Domains (6) summary
      cd09327
      Location:86137
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:142197
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:213264
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:272327
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:730765
      VHP; Villin headpiece domain
      cl14106
      Location:567627
      Rifin_STEVOR; Rifin/stevor family
    3. XM_005269818.1XP_005269875.1  

      See identical proteins and their annotated locations for XP_005269875.1

      UniProtKB/Swiss-Prot
      O14639
      Conserved Domains (6) summary
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:713748
      VHP; Villin headpiece domain
      cl14106
      Location:550610
      Rifin_STEVOR; Rifin/stevor family
    4. XM_006717837.1XP_006717900.1  

      Conserved Domains (5) summary
      smart00153
      Location:753788
      VHP; Villin headpiece domain
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    5. XM_011539802.1XP_011538104.1  

      Conserved Domains (6) summary
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:737772
      VHP; Villin headpiece domain
      cl14106
      Location:574634
      Rifin_STEVOR; Rifin/stevor family
    6. XM_005269824.1XP_005269881.1  

      See identical proteins and their annotated locations for XP_005269881.1

      UniProtKB/TrEMBL
      B7Z4H1
      Conserved Domains (6) summary
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:620655
      VHP; Villin headpiece domain
      cl14106
      Location:457517
      Rifin_STEVOR; Rifin/stevor family
    7. XM_006717838.1XP_006717901.1  

      Conserved Domains (6) summary
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:737772
      VHP; Villin headpiece domain
      cl14106
      Location:574634
      Rifin_STEVOR; Rifin/stevor family
    8. XM_011539801.1XP_011538103.1  

      Conserved Domains (5) summary
      cd09327
      Location:52103
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:108163
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:179230
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:238293
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:766801
      VHP; Villin headpiece domain
    9. XM_011539806.1XP_011538108.1  

      Conserved Domains (5) summary
      cd09328
      Location:358
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:509544
      VHP; Villin headpiece domain
      cl14106
      Location:308406
      Rifin_STEVOR; Rifin/stevor family
    10. XM_011539804.1XP_011538106.1  

      Conserved Domains (5) summary
      cd09328
      Location:358
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:556591
      VHP; Villin headpiece domain
      cl14106
      Location:393453
      Rifin_STEVOR; Rifin/stevor family
    11. XM_005269826.1XP_005269883.1  

      See identical proteins and their annotated locations for XP_005269883.1

      Conserved Domains (3) summary
      pfam02209
      Location:497532
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:334394
      Rifin_STEVOR; Rifin/stevor family
    12. XM_005269830.3XP_005269887.1  

      See identical proteins and their annotated locations for XP_005269887.1

      UniProtKB/TrEMBL
      B4DQA3
      Conserved Domains (3) summary
      pfam02209
      Location:345380
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:144242
      Rifin_STEVOR; Rifin/stevor family
    13. XM_005269828.3XP_005269885.1  

      See identical proteins and their annotated locations for XP_005269885.1

      UniProtKB/Swiss-Prot
      O14639
      Conserved Domains (3) summary
      pfam02209
      Location:392427
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:229289
      Rifin_STEVOR; Rifin/stevor family
    14. XM_005269827.3XP_005269884.1  

      See identical proteins and their annotated locations for XP_005269884.1

      Conserved Domains (3) summary
      pfam02209
      Location:469504
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:306366
      Rifin_STEVOR; Rifin/stevor family
    15. XM_006717846.2XP_006717909.1  

      See identical proteins and their annotated locations for XP_006717909.1

      Conserved Domains (3) summary
      pfam02209
      Location:497532
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:334394
      Rifin_STEVOR; Rifin/stevor family
    16. XM_006717848.1XP_006717911.1  

      Conserved Domains (3) summary
      pfam02209
      Location:394429
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:231291
      Rifin_STEVOR; Rifin/stevor family
    17. XM_006717847.1XP_006717910.1  

      See identical proteins and their annotated locations for XP_006717910.1

      Conserved Domains (3) summary
      pfam02209
      Location:469504
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:306366
      Rifin_STEVOR; Rifin/stevor family

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      116474653..116728179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)