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    KRT19 keratin 19, type I [ Homo sapiens (human) ]

    Gene ID: 3880, updated on 30-Jun-2015
    Official Symbol
    KRT19provided by HGNC
    Official Full Name
    keratin 19, type Iprovided by HGNC
    Primary source
    HGNC:HGNC:6436
    See related
    Ensembl:ENSG00000171345; HPRD:01007; MIM:148020; Vega:OTTHUMG00000133422
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K19; CK19; K1CS
    Summary
    The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
    Orthologs
    See KRT19 in Epigenomics, MapViewer
    Location:
    17q21.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (41523617..41528389, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39679869..39684641, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 13, type I Neighboring gene keratin 15, type I Neighboring gene microRNA 6510 Neighboring gene long intergenic non-protein coding RNA 974 Neighboring gene keratin 9, type I

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC15366

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    structural constituent of muscle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation involved in embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sarcomere organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    costamere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dystrophin-associated glycoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    terminal web IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    keratin, type I cytoskeletal 19
    Names
    40-kDa keratin intermediate filament
    CK-19
    cytokeratin 19
    cytokeratin-19
    keratin, type I, 40-kd
    keratin-19

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012285.1 RefSeqGene

      Range
      5001..9773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002276.4NP_002267.2  keratin, type I cytoskeletal 19

      See identical proteins and their annotated locations for NP_002267.2

      Status: REVIEWED

      Source sequence(s)
      BC007628, BG490639, BP328445, DA068330
      Consensus CDS
      CCDS11399.1
      UniProtKB/Swiss-Prot
      P08727
      Related
      ENSP00000355124, OTTHUMP00000164620, ENST00000361566, OTTHUMT00000257285
      Conserved Domains (1) summary
      pfam00038
      Location:79388
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      41523617..41528389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      39915178..39919959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)