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    KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 [ Homo sapiens (human) ]

    Gene ID: 3790, updated on 26-Jun-2015
    Official Symbol
    KCNS3provided by HGNC
    Official Full Name
    potassium voltage-gated channel, modifier subfamily S, member 3provided by HGNC
    Primary source
    HGNC:HGNC:6302
    See related
    Ensembl:ENSG00000170745; HPRD:04865; MIM:603888; Vega:OTTHUMG00000044150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KV9.3
    Summary
    Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
    Orthologs
    See KCNS3 in Epigenomics, MapViewer
    Location:
    2p24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (17877847..17932961)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (18059105..18114225)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mesogenin 1 Neighboring gene zona pellucida glycoprotein AX, pseudogene Neighboring gene uncharacterized LOC105373451 Neighboring gene uncharacterized LOC105373452

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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      Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, organism-specific biosystemGlucagon-like Peptide-1 (GLP-1) is secreted by L-cells in the intestine in response to glucose and fatty acids. GLP-1 circulates to the beta cells of the pancreas where it binds a G-protein coupled r...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Potassium Channels, organism-specific biosystem (from REACTOME)
      Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
    • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
      Regulation of insulin secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...
    • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
      Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC9481

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    delayed rectifier potassium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    potassium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    energy reserve metabolic process TAS
    Traceable Author Statement
    more info
     
    potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    potassium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of insulin secretion TAS
    Traceable Author Statement
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    synaptic transmission TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    potassium voltage-gated channel subfamily S member 3
    Names
    potassium voltage-gated channel subfamily S member 3
    Shab-related delayed-rectifier K+ channel alpha subunit 3
    delayed-rectifier K(+) channel alpha subunit 3
    potassium voltage-gated channel delayed-rectifier protein S3
    potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
    voltage-gated potassium channel protein Kv9.3
    voltage-gated potassium channel subunit Kv9.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012873.1 RefSeqGene

      Range
      4170..59281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282428.1NP_001269357.1  potassium voltage-gated channel subfamily S member 3

      See identical proteins and their annotated locations for NP_001269357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' terminal exon, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK314451, BC015947, DA921825
      Consensus CDS
      CCDS1692.1
      UniProtKB/Swiss-Prot
      Q9BQ31
      Related
      ENSP00000385968, OTTHUMP00000200486, ENST00000403915, OTTHUMT00000323808
      Conserved Domains (3) summary
      pfam00520
      Location:225405
      Ion_trans; Ion transport protein
      pfam02214
      Location:17116
      BTB_2; BTB/POZ domain
      pfam07885
      Location:326406
      Ion_trans_2; Ion channel
    2. NM_002252.4NP_002243.3  potassium voltage-gated channel subfamily S member 3

      See identical proteins and their annotated locations for NP_002243.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AK314451, BC015947
      Consensus CDS
      CCDS1692.1
      UniProtKB/Swiss-Prot
      Q9BQ31
      Related
      ENSP00000305824, OTTHUMP00000149986, ENST00000304101, OTTHUMT00000241660
      Conserved Domains (3) summary
      pfam00520
      Location:225405
      Ion_trans; Ion transport protein
      pfam02214
      Location:17116
      BTB_2; BTB/POZ domain
      pfam07885
      Location:326406
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      17877847..17932961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532825.1XP_011531127.1  

      See identical proteins and their annotated locations for XP_011531127.1

      Conserved Domains (3) summary
      pfam00520
      Location:225405
      Ion_trans; Ion transport protein
      pfam02214
      Location:17116
      BTB_2; BTB/POZ domain
      pfam07885
      Location:326406
      Ion_trans_2; Ion channel

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      17988380..18043592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)