Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 [ Homo sapiens (human) ]

    Gene ID: 3755, updated on 26-Jun-2015
    Official Symbol
    KCNG1provided by HGNC
    Official Full Name
    potassium channel, voltage gated modifier subfamily G, member 1provided by HGNC
    Primary source
    HGNC:HGNC:6248
    See related
    Ensembl:ENSG00000026559; HPRD:04809; MIM:603788; Vega:OTTHUMG00000032745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K13; kH2; KCNG; KV6.1
    Summary
    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]
    Orthologs
    See KCNG1 in Epigenomics, MapViewer
    Location:
    20q13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (51003656..51023176, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49620193..49639675, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ADNP antisense RNA 1 Neighboring gene dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene uncharacterized LOC105372661 Neighboring gene uncharacterized LOC105372662 Neighboring gene ribosomal protein SA pseudogene 1

    NHGRI GWAS Catalog

    Description
    Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of KCNG1 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
    Knockdown of potassium voltage-gated channel, subfamily G, member 1 (KCNG1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Potassium Channels, organism-specific biosystem (from REACTOME)
      Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
    • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
      Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC12878

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    potassium channel activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    potassium ion transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic transmission TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    colocalizes_with voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    potassium voltage-gated channel subfamily G member 1
    Names
    potassium voltage-gated channel subfamily G member 1
    potassium channel KH2
    potassium channel Kv6.1
    potassium voltage-gated channel, subfamily G, member 1
    voltage-gated potassium channel subunit Kv6.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002237.3NP_002228.2  potassium voltage-gated channel subfamily G member 1

      See identical proteins and their annotated locations for NP_002228.2

      Status: REVIEWED

      Source sequence(s)
      AF033383, BC046629, BG029104, CN301212, CN480356, DA580190, DA684016
      Consensus CDS
      CCDS13436.1
      UniProtKB/TrEMBL
      Q86Y85
      UniProtKB/Swiss-Prot
      Q9UIX4
      Related
      ENSP00000360626, OTTHUMP00000043416, ENST00000371571, OTTHUMT00000079726
      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

      Range
      51003656..51023176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528804.1XP_011527106.1  

      See identical proteins and their annotated locations for XP_011527106.1

      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel
    2. XM_011528800.1XP_011527102.1  

      See identical proteins and their annotated locations for XP_011527102.1

      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel
    3. XM_011528802.1XP_011527104.1  

      See identical proteins and their annotated locations for XP_011527104.1

      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel
    4. XM_011528801.1XP_011527103.1  

      See identical proteins and their annotated locations for XP_011527103.1

      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel
    5. XM_011528806.1XP_011527108.1  

      See identical proteins and their annotated locations for XP_011527108.1

      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel
    6. XM_006723785.2XP_006723848.1  

      See identical proteins and their annotated locations for XP_006723848.1

      UniProtKB/Swiss-Prot
      Q9UIX4
      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel
    7. XM_011528803.1XP_011527105.1  

      See identical proteins and their annotated locations for XP_011527105.1

      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel
    8. XM_011528805.1XP_011527107.1  

      See identical proteins and their annotated locations for XP_011527107.1

      Conserved Domains (3) summary
      pfam00520
      Location:270456
      Ion_trans; Ion transport protein
      pfam02214
      Location:65164
      BTB_2; BTB/POZ domain
      pfam07885
      Location:383460
      Ion_trans_2; Ion channel

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      49525802..49545284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172318.2: Suppressed sequence

      Description
      NM_172318.2: This RefSeq was temporarily suppressed because its source, BC006367.1, was from a cancerous cell line. The remaining transcript data that support this splice variant are of incomplete length.