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    INPP5A inositol polyphosphate-5-phosphatase, 40kDa [ Homo sapiens (human) ]

    Gene ID: 3632, updated on 26-Jun-2015
    Official Symbol
    INPP5Aprovided by HGNC
    Official Full Name
    inositol polyphosphate-5-phosphatase, 40kDaprovided by HGNC
    Primary source
    HGNC:HGNC:6076
    See related
    Ensembl:ENSG00000068383; HPRD:02521; MIM:600106; Vega:OTTHUMG00000019293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5PTASE
    Summary
    The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]
    Orthologs
    See INPP5A in Epigenomics, MapViewer
    Location:
    10q26.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (132537784..132783480)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134351283..134596984)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378570 Neighboring gene uncharacterized LOC105378569 Neighboring gene chromosome 10 open reading frame 91 Neighboring gene NK6 homeobox 2 Neighboring gene uncharacterized LOC105378571 Neighboring gene cilia and flagella associated protein 46

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC116947, MGC116949, DKFZp434A1721

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    PH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol-polyphosphate 5-phosphatase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    type I inositol 1,4,5-trisphosphate 5-phosphatase
    Names
    type I inositol 1,4,5-trisphosphate 5-phosphatase
    43 kDa inositol polyphosphate 5-phophatase
    CTCL tumor antigen HD-CL-02
    InsP3 5-phosphatase
    inositol polyphosphate-5-phosphatase, 40kD
    inositol trisphosphate-5-phosphatase, 40kD
    type I inositol-1,4,5-trisphosphate 5-phophatase
    type I inositol-1,4,5-trisphosphate 5-phosphatase
    NP_005530.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005539.3NP_005530.3  type I inositol 1,4,5-trisphosphate 5-phosphatase

      See identical proteins and their annotated locations for NP_005530.3

      Status: REVIEWED

      Source sequence(s)
      AF273055, AL392043, BC096280
      Consensus CDS
      CCDS7669.2
      UniProtKB/Swiss-Prot
      Q14642
      UniProtKB/TrEMBL
      Q8N6C1
      Related
      ENSP00000357583, OTTHUMP00000020775, ENST00000368594, OTTHUMT00000051085
      Conserved Domains (1) summary
      cd09092
      Location:10394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      132537784..132783480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539768.1XP_011538070.1  

      Conserved Domains (1) summary
      cl00490
      Location:13304
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RNA

    1. XR_945735.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      134632664..134878465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)