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    CYR61 cysteine-rich, angiogenic inducer, 61 [ Homo sapiens (human) ]

    Gene ID: 3491, updated on 28-Jun-2015
    Official Symbol
    CYR61provided by HGNC
    Official Full Name
    cysteine-rich, angiogenic inducer, 61provided by HGNC
    Primary source
    HGNC:HGNC:2654
    See related
    Ensembl:ENSG00000142871; HPRD:09089; MIM:602369; Vega:OTTHUMG00000010577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCN1; GIG1; IGFBP10
    Summary
    The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
    Orthologs
    See CYR61 in Epigenomics, MapViewer
    Location:
    1p22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (85580761..85583967)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86046444..86049650)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC646626 Neighboring gene B-cell CLL/lymphoma 10 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene uncharacterized LOC105378822 Neighboring gene zinc finger, HIT-type containing 6

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process involved in heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    atrial septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    atrioventricular valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    chondroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    chorio-allantoic fusion IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    intussusceptive angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    labyrinthine layer blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of osteoblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing, spreading of cells IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteinaceous extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    protein CYR61
    Names
    protein CYR61
    CCN family member 1
    IBP-10
    IGF-binding protein 10
    IGFBP-10
    cysteine-rich heparin-binding protein 61
    cysteine-rich, anigogenic inducer, 61
    insulin-like growth factor-binding protein 10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001554.4NP_001545.2  protein CYR61 precursor

      See identical proteins and their annotated locations for NP_001545.2

      Status: REVIEWED

      Source sequence(s)
      BC009199, BP387218, DA764894
      Consensus CDS
      CCDS706.1
      UniProtKB/Swiss-Prot
      O00622
      UniProtKB/TrEMBL
      Q6FI18
      Related
      ENSP00000398736, OTTHUMP00000012303, ENST00000451137, OTTHUMT00000029187
      Conserved Domains (4) summary
      smart00214
      Location:100159
      VWC; von Willebrand factor (vWF) type C domain
      pfam00090
      Location:232272
      TSP_1; Thrombospondin type 1 domain
      pfam00219
      Location:3278
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:293375
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      85580761..85583967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      86161864..86165070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)