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    HOXA11 homeobox A11 [ Homo sapiens (human) ]

    Gene ID: 3207, updated on 26-Jun-2015
    Official Symbol
    HOXA11provided by HGNC
    Official Full Name
    homeobox A11provided by HGNC
    Primary source
    HGNC:HGNC:5101
    See related
    Ensembl:ENSG00000005073; HPRD:00846; MIM:142958; Vega:OTTHUMG00000023437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX1; HOX1I
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
    Orthologs
    See HOXA11 in Epigenomics, MapViewer
    Location:
    7p15.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (27181157..27185216, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27220776..27224835, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene HOXA10 antisense RNA Neighboring gene microRNA 196b Neighboring gene homeobox A10 Neighboring gene HOXA11 antisense RNA Neighboring gene homeobox A13

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in ureteric bud morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cartilage development involved in endochondral bone morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    developmental growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dorsal/ventral pattern formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic limb morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    embryonic skeletal joint morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    mesodermal cell fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metanephros development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proximal/distal pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-DNA complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    homeobox protein Hox-A11
    Names
    homeobox protein Hox-A11
    homeo box 1I
    homeobox protein HOXA11
    homeobox protein Hox-1I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012079.1 RefSeqGene

      Range
      5001..9060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005523.5NP_005514.1  homeobox protein Hox-A11

      See identical proteins and their annotated locations for NP_005514.1

      Status: REVIEWED

      Source sequence(s)
      AC004080, BC040948
      Consensus CDS
      CCDS5411.1
      UniProtKB/Swiss-Prot
      P31270
      Related
      ENSP00000006015, OTTHUMP00000217288, ENST00000006015, OTTHUMT00000358754
      Conserved Domains (2) summary
      pfam12045
      Location:25168
      DUF3528; Protein of unknown function (DUF3528)
      cd00086
      Location:242298
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

      Range
      27181157..27185216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      27220497..27224560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)