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    CXCL2 chemokine (C-X-C motif) ligand 2 [ Homo sapiens (human) ]

    Gene ID: 2920, updated on 27-Jun-2015
    Official Symbol
    CXCL2provided by HGNC
    Official Full Name
    chemokine (C-X-C motif) ligand 2provided by HGNC
    Primary source
    HGNC:HGNC:4603
    See related
    Ensembl:ENSG00000081041; HPRD:00741; MIM:139110; Vega:OTTHUMG00000160865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
    Summary
    This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
    Orthologs
    See CXCL2 in Epigenomics, MapViewer
    Location:
    4q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (74097035..74099280, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74962752..74964997, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene pro-platelet basic protein pseudogene 2 Neighboring gene coiled-coil domain containing 90B pseudogene Neighboring gene uncharacterized LOC105377277 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene uncharacterized LOC105377276 Neighboring gene epithelial mitogen

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of CXCL2 expression as compared to untreated control PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of chemokine (C-X-C motif) ligand 2 (CXCL2) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of leukocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    C-X-C motif chemokine 2
    Names
    C-X-C motif chemokine 2
    GRO2 oncogene
    MGSA beta
    MIP2-alpha
    gro-beta
    growth-regulated protein beta
    macrophage inflammatory protein 2-alpha
    melanoma growth stimulatory activity beta

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002089.3NP_002080.1  C-X-C motif chemokine 2 precursor

      See identical proteins and their annotated locations for NP_002080.1

      Status: REVIEWED

      Source sequence(s)
      BC053653, BX334969, X53799
      Consensus CDS
      CCDS34008.1
      UniProtKB/TrEMBL
      A0A024RDD9
      UniProtKB/Swiss-Prot
      P19875
      Related
      ENSP00000427279, OTTHUMP00000219185, ENST00000508487, OTTHUMT00000362731
      Conserved Domains (1) summary
      cd00273
      Location:40102
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      74097035..74099280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      74998593..75000838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)