RGMB repulsive guidance molecule BMP co-receptor b [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGMBprovided by HGNC
Official Full Name: repulsive guidance molecule BMP co-receptor bprovided by HGNC
Primary source: HGNC:HGNC:26896
See related: Ensembl:ENSG00000174136 MIM:612687; AllianceGenome:HGNC:26896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DRAGON
Summary: RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Expression: Ubiquitous expression in brain (RPKM 10.1), skin (RPKM 10.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q15

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (98768632..98796494)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (99271925..99299789)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (98104336..98132198)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
Title: RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.
RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
Title: RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4.
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Title: Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex.
Our results demonstrate that RGMB is an important inhibitor of non-small cell lung cancer metastasis and that low RGMB expression is a novel predictor or a poor prognosis.
Title: Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer.
Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC mouse model and in human patients.
Title: Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth.
RGMB was down-regulation in non-small cell lung cancer.
Title: Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer.
Study highlights the potential importance of RGMb in propagating pro-angiogenic effects of HGF and BMP-7.
Title: Tumour angiogenesis and repulsive guidance molecule b: a role in HGF- and BMP-7-mediated angiogenesis.
two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner.
Title: Structure of the repulsive guidance molecule (RGM)-neogenin signaling hub.
current data firstly revealed that RGMB may act as a negative regulator in breast cancer through BMP signaling
Title: Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling.
The expression of RGMA, RGMB and RGMC was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues
Title: Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Variants in several genomic regions associated with asperger disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N24666 (e-PCR)
- UniSTS:37243

RH44931 (e-PCR)
- UniSTS:75457

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum-Golgi intermediate compartment	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: repulsive guidance molecule B

Names: DRG11-responsive axonal guidance and outgrowth of neurite; RGM domain family, member B; repulsive guidance molecule family member b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012761.3 → NP_001012779.2 repulsive guidance molecule B isoform 2

See identical proteins and their annotated locations for NP_001012779.2

Status: VALIDATED

Source sequence(s)

AC008522, AK054622, BC020513, BC067736

Consensus CDS

CCDS47251.1

UniProtKB/TrEMBL

J3KNF6

Related

ENSP00000308219.7, ENST00000308234.11

Conserved Domains (2) summary

pfam06534
Location:267 → 441

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:95 → 262

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001366508.1 → NP_001353437.1 repulsive guidance molecule B isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC008522

Consensus CDS

CCDS93751.1

UniProtKB/Swiss-Prot

D6R9A0, Q6NW40, Q8NC92

Related

ENSP00000423256.1, ENST00000513185.3

Conserved Domains (2) summary

pfam06534
Location:226 → 400

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:54 → 221

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001366509.1 → NP_001353438.1 repulsive guidance molecule B isoform 2

Status: VALIDATED

Source sequence(s)

AC008522

Consensus CDS

CCDS47251.1

UniProtKB/TrEMBL

J3KNF6

Conserved Domains (2) summary

pfam06534
Location:267 → 441

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:95 → 262

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001366510.1 → NP_001353439.1 repulsive guidance molecule B isoform 2

Status: VALIDATED

Source sequence(s)

AC008522

Consensus CDS

CCDS47251.1

UniProtKB/TrEMBL

J3KNF6

Conserved Domains (2) summary

pfam06534
Location:267 → 441

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:95 → 262

RGM_N; Repulsive guidance molecule (RGM) N-terminus
NM_001366511.1 → NP_001353440.1 repulsive guidance molecule B isoform 3

Status: VALIDATED

Source sequence(s)

AC008522

Conserved Domains (2) summary

pfam06534
Location:266 → 440

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:94 → 261

RGM_N; Repulsive guidance molecule (RGM) N-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

98768632..98796494

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047417124.1 → XP_047273080.1 repulsive guidance molecule B isoform X1
XM_047417125.1 → XP_047273081.1 repulsive guidance molecule B isoform X3

UniProtKB/Swiss-Prot

D6R9A0, Q6NW40, Q8NC92
XM_011543345.3 → XP_011541647.1 repulsive guidance molecule B isoform X2

See identical proteins and their annotated locations for XP_011541647.1

UniProtKB/TrEMBL

J3KNF6

Conserved Domains (2) summary

pfam06534
Location:267 → 441

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:95 → 262

RGM_N; Repulsive guidance molecule (RGM) N-terminus
XM_011543346.3 → XP_011541648.1 repulsive guidance molecule B isoform X4

Conserved Domains (2) summary

pfam06534
Location:185 → 364

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:13 → 180

RGM_N; Repulsive guidance molecule (RGM) N-terminus

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

99271925..99299789

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352457.1 → XP_054208432.1 repulsive guidance molecule B isoform X1
XM_054352458.1 → XP_054208433.1 repulsive guidance molecule B isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_173670.2: Suppressed sequence

Description

NM_173670.2: This RefSeq was permanently suppressed because there is insufficient support for the alternate terminal exon represented by this transcript.