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    IL4I1 interleukin 4 induced 1 [ Homo sapiens (human) ]

    Gene ID: 259307, updated on 26-Jun-2015
    Official Symbol
    IL4I1provided by HGNC
    Official Full Name
    interleukin 4 induced 1provided by HGNC
    Primary source
    HGNC:HGNC:19094
    See related
    Ensembl:ENSG00000104951; HPRD:17146; MIM:609742; Vega:OTTHUMG00000183377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAO; FIG1; LAAO
    Summary
    This gene encodes a protein with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor. The expression of this gene can be induced by interleukin 4 in B cells, however, expression of transcripts containing the first two exons of the upstream gene is found in other cell types. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
    Orthologs
    See IL4I1 in Epigenomics, MapViewer
    Location:
    19q13.3-q13.4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (49889654..49929539, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50392911..50432796, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 (proline-rich) Neighboring gene TBC1 domain family, member 17 Neighboring gene microRNA 4750 Neighboring gene nucleoporin 62kDa Neighboring gene activating transcription factor 5 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig-like lectin 11

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    L-amino-acid oxidase activity EXP
    Inferred from Experiment
    more info
     
    Process Evidence Code Pubs
    L-phenylalanine catabolic process TAS
    Traceable Author Statement
    more info
     
    cellular nitrogen compound metabolic process TAS
    Traceable Author Statement
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    L-amino-acid oxidase
    Names
    L-amino-acid oxidase
    Fig-1 protein
    IL4-induced protein 1
    interleukin four induced 1
    NP_001244946.1
    NP_001244947.1
    NP_690863.1
    NP_758962.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021170.1 RefSeqGene

      Range
      4967..44852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258017.1NP_001244946.1  L-amino-acid oxidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001244946.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC118342, DQ079589
      Consensus CDS
      CCDS12786.1
      UniProtKB/Swiss-Prot
      Q96RQ9
      Conserved Domains (2) summary
      pfam01593
      Location:91523
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:86142
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    2. NM_001258018.1NP_001244947.1  L-amino-acid oxidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_001244947.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC118342, DQ079588
      Consensus CDS
      CCDS12786.1
      UniProtKB/Swiss-Prot
      Q96RQ9
      Related
      ENSP00000472474, OTTHUMP00000271571, ENST00000595948, OTTHUMT00000466416
      Conserved Domains (2) summary
      pfam01593
      Location:91523
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:86142
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    3. NM_152899.1NP_690863.1  L-amino-acid oxidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_690863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding region compared to variant 2. The resulting isoform (1) contains a distinct and shorter N-terminus, as compared to isoform 2. This transcript contains the first two exons of the upstream and is expressed from a different promoter.
      Source sequence(s)
      AF293462
      Consensus CDS
      CCDS12787.1
      UniProtKB/Swiss-Prot
      Q96RQ9
      Related
      ENSP00000375702, OTTHUMP00000271568, ENST00000391826, OTTHUMT00000466413
      Conserved Domains (2) summary
      pfam01593
      Location:69501
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:64120
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    4. NM_172374.2NP_758962.1  L-amino-acid oxidase isoform 2 precursor

      See identical proteins and their annotated locations for NP_758962.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes a longer isoform (2). Variants 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC118342, DQ079587
      Consensus CDS
      CCDS12786.1
      UniProtKB/Swiss-Prot
      Q96RQ9
      Related
      ENSP00000342557, OTTHUMP00000271570, ENST00000341114, OTTHUMT00000466415
      Conserved Domains (2) summary
      pfam01593
      Location:91523
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:86142
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RNA

    1. NR_047577.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC011452, AC118342, AJ880389

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

      Range
      49889654..49929539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      50394747..50434624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)