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    RHOBTB2 Rho-related BTB domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 23221, updated on 26-Jun-2015
    Official Symbol
    RHOBTB2provided by HGNC
    Official Full Name
    Rho-related BTB domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:18756
    See related
    Ensembl:ENSG00000008853; HPRD:06300; MIM:607352; Vega:OTTHUMG00000097827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DBC2
    Summary
    The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    See RHOBTB2 in Epigenomics, MapViewer
    Location:
    8p21.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (22987258..23020197)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (22844930..22877710)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine-binding protein 4 Neighboring gene uncharacterized LOC101929237 Neighboring gene uncharacterized LOC105379323 Neighboring gene tumor necrosis factor receptor superfamily, member 10b Neighboring gene tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain pseudogene Neighboring gene uncharacterized LOC254896 Neighboring gene tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0717

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    rho-related BTB domain-containing protein 2
    Names
    rho-related BTB domain-containing protein 2
    deleted in breast cancer 2 gene protein
    p83

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160036.1NP_001153508.1  rho-related BTB domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001153508.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA641575, AB018260, AK292863, AY009093, BC034917, BG255120
      Consensus CDS
      CCDS55210.1
      UniProtKB/Swiss-Prot
      Q9BYZ6
      Conserved Domains (4) summary
      cd01873
      Location:35229
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00225
      Location:523615
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00071
      Location:38230
      Ras; Ras family
      cl02518
      Location:289326
      BTB; BTB/POZ domain
    2. NM_001160037.1NP_001153509.1  rho-related BTB domain-containing protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA641575, AB018260, AK292863, AY009093, BG255120, DA289763
      Consensus CDS
      CCDS55211.1
      UniProtKB/Swiss-Prot
      Q9BYZ6
      Related
      ENSP00000429141, OTTHUMP00000224749, ENST00000522948, OTTHUMT00000375200
      Conserved Domains (4) summary
      cd01873
      Location:20214
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00225
      Location:508600
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00071
      Location:23215
      Ras; Ras family
      cl02518
      Location:274311
      BTB; BTB/POZ domain
    3. NM_015178.2NP_055993.2  rho-related BTB domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_055993.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AA641575, AB018260, AK292863, AY009093, BG255120
      Consensus CDS
      CCDS6034.1
      UniProtKB/Swiss-Prot
      Q9BYZ6
      Related
      ENSP00000251822, OTTHUMP00000123494, ENST00000251822, OTTHUMT00000215101
      Conserved Domains (4) summary
      cd01873
      Location:13207
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00225
      Location:501593
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00071
      Location:16208
      Ras; Ras family
      cl02518
      Location:267304
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

      Range
      22987258..23020197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716315.2XP_006716378.1  

      See identical proteins and their annotated locations for XP_006716378.1

      UniProtKB/Swiss-Prot
      Q9BYZ6
      Conserved Domains (4) summary
      cd01873
      Location:35229
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00225
      Location:523615
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00071
      Location:38230
      Ras; Ras family
      cl02518
      Location:289326
      BTB; BTB/POZ domain
    2. XM_011544454.1XP_011542756.1  

      Conserved Domains (4) summary
      cd01873
      Location:39233
      RhoBTB; RhoBTB protein is an atypical member of the Rho family of small GTPases
      smart00225
      Location:527619
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00071
      Location:42234
      Ras; Ras family
      cl02518
      Location:293330
      BTB; BTB/POZ domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      23047120..23079900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)