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    Top2a topoisomerase (DNA) II alpha [ Mus musculus (house mouse) ]

    Gene ID: 21973, updated on 27-Jun-2015
    Official Symbol
    Top2aprovided by MGI
    Official Full Name
    topoisomerase (DNA) II alphaprovided by MGI
    Primary source
    MGI:MGI:98790
    See related
    Ensembl:ENSMUSG00000020914; Vega:OTTMUSG00000006446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Top-2
    Orthologs
    See Top2a in Epigenomics, MapViewer
    Location:
    11 D; 11 62.91 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (98992947..99024206, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (98854261..98885503, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, alpha Neighboring gene predicted gene, 38986 Neighboring gene gap junction protein, delta 3 Neighboring gene insulin-like growth factor binding protein 4 Neighboring gene tensin 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding, bending ISO
    Inferred from Sequence Orthology
    more info
     
    DNA topoisomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA topoisomerase type II (ATP-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA topoisomerase type II (ATP-hydrolyzing) activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    DNA topoisomerase type II (ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    structure-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA ligation ISO
    Inferred from Sequence Orthology
    more info
     
    DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA topological change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA topological change ISO
    Inferred from Sequence Orthology
    more info
     
    DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apoptotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apoptotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic DNA integrity checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    DNA topoisomerase complex (ATP-hydrolyzing) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA topoisomerase complex (ATP-hydrolyzing) ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with centriole ISO
    Inferred from Sequence Orthology
    more info
     
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    DNA topoisomerase 2-alpha
    Names
    DNA topoisomerase 2-alpha
    DNA Topoisomerase II alpha
    DNA topoisomerase II, alpha isozyme
    NP_035753.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011623.2NP_035753.2  DNA topoisomerase 2-alpha

      See identical proteins and their annotated locations for NP_035753.2

      Status: VALIDATED

      Source sequence(s)
      AL591067
      Consensus CDS
      CCDS25370.1
      UniProtKB/Swiss-Prot
      Q01320
      Related
      ENSMUSP00000068896, OTTMUSP00000006845, ENSMUST00000068031, OTTMUST00000014727
      Conserved Domains (6) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00075
      Location:80181
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241441
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14311519
      DTHCT; DTHCT (NUC029) region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

      Range
      98992947..99024206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533155.1XP_006533218.1  

      See identical proteins and their annotated locations for XP_006533218.1

      Conserved Domains (6) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00075
      Location:80181
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241440
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14301518
      DTHCT; DTHCT (NUC029) region
    2. XM_006533154.1XP_006533217.1  

      See identical proteins and their annotated locations for XP_006533217.1

      Conserved Domains (6) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00075
      Location:80181
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241440
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14301518
      DTHCT; DTHCT (NUC029) region
    3. XM_006533153.1XP_006533216.1  

      See identical proteins and their annotated locations for XP_006533216.1

      UniProtKB/Swiss-Prot
      Q01320
      Conserved Domains (6) summary
      cd03365
      Location:454574
      TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
      cd00075
      Location:80181
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cd00187
      Location:7101171
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes ...
      cd03481
      Location:264416
      TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
      PTZ00108
      Location:241441
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam08070
      Location:14311519
      DTHCT; DTHCT (NUC029) region

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      108658802..108690006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)